Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011043523> ?p ?o ?g. }
- W2011043523 endingPage "396" @default.
- W2011043523 startingPage "390" @default.
- W2011043523 abstract "Striated muscles (skeletal and cardiac) are major physiological targets of insulin and this hormone triggers complex signaling pathways regulating cell growth and energy metabolism. Insulin increases glucose uptake into muscle cells by stimulating glucose transporter (GLUT4) translocation from intracellular compartments to the cell surface. The canonical insulin-triggered signaling cascade controlling this process is constituted by well-mapped tyrosine, lipid and serine/threonine phosphorylation reactions. In parallel to these signals, recent findings reveal insulin-dependent Ca2+ mobilization in skeletal muscle cells and cardiomyocytes. Specifically, insulin activates the sarco-endoplasmic reticulum (SER) channels that release Ca2+ into the cytosol i.e., the Ryanodine Receptor (RyR) and the inositol 1,4,5-triphosphate receptor (IP3R). In skeletal muscle cells, a rapid, insulin-triggered Ca2+ release occurs through RyR, that is brought about upon S-glutathionylation of cysteine residues in the channel by reactive oxygen species (ROS) produced by the early activation of the NADPH oxidase (NOX2). In cardiomyocytes insulin induces a fast and transient increase in cytoplasmic [Ca2+]i trough L-type Ca2+ channels activation. In both cell types, a relatively slower Ca2+ release also occurs through IP3R activation, and is required for GLUT4 translocation and glucose uptake. The insulin-dependent Ca2+ released from IP3R of skeletal muscle also promotes mitochondrial Ca2+ uptake. We review here these actions of insulin on intracellular Ca2+ channel activation and their impact on GLUT4 traffic in muscle cells, as well as other implications of insulin-dependent Ca2+ release from the SER." @default.
- W2011043523 created "2016-06-24" @default.
- W2011043523 creator A5010563191 @default.
- W2011043523 creator A5022277890 @default.
- W2011043523 creator A5040659996 @default.
- W2011043523 creator A5064467789 @default.
- W2011043523 date "2014-11-01" @default.
- W2011043523 modified "2023-10-17" @default.
- W2011043523 title "Calcium signaling in insulin action on striated muscle" @default.
- W2011043523 cites W1506981847 @default.
- W2011043523 cites W1546273936 @default.
- W2011043523 cites W1579749290 @default.
- W2011043523 cites W1601262489 @default.
- W2011043523 cites W1968126815 @default.
- W2011043523 cites W1970948321 @default.
- W2011043523 cites W1976653524 @default.
- W2011043523 cites W1977574098 @default.
- W2011043523 cites W1977746407 @default.
- W2011043523 cites W1986467292 @default.
- W2011043523 cites W1989507960 @default.
- W2011043523 cites W1995268447 @default.
- W2011043523 cites W1995626771 @default.
- W2011043523 cites W1997560040 @default.
- W2011043523 cites W2002475003 @default.
- W2011043523 cites W2006356034 @default.
- W2011043523 cites W2013482796 @default.
- W2011043523 cites W2017709939 @default.
- W2011043523 cites W2023750276 @default.
- W2011043523 cites W2023974577 @default.
- W2011043523 cites W2024048159 @default.
- W2011043523 cites W2029181957 @default.
- W2011043523 cites W2032132422 @default.
- W2011043523 cites W2037525354 @default.
- W2011043523 cites W2038586266 @default.
- W2011043523 cites W2044907733 @default.
- W2011043523 cites W2045935504 @default.
- W2011043523 cites W2050683379 @default.
- W2011043523 cites W2050824263 @default.
- W2011043523 cites W2058763646 @default.
- W2011043523 cites W2058920539 @default.
- W2011043523 cites W2059907698 @default.
- W2011043523 cites W2064426263 @default.
- W2011043523 cites W2066696433 @default.
- W2011043523 cites W2066994490 @default.
- W2011043523 cites W2071150139 @default.
- W2011043523 cites W2072174276 @default.
- W2011043523 cites W2074206560 @default.
- W2011043523 cites W2074766103 @default.
- W2011043523 cites W2078506965 @default.
- W2011043523 cites W2080854025 @default.
- W2011043523 cites W2084240586 @default.
- W2011043523 cites W2084484618 @default.
- W2011043523 cites W2085048595 @default.
- W2011043523 cites W2085128107 @default.
- W2011043523 cites W2090328262 @default.
- W2011043523 cites W2090843533 @default.
- W2011043523 cites W2092944630 @default.
- W2011043523 cites W2095310103 @default.
- W2011043523 cites W2096286606 @default.
- W2011043523 cites W2097210443 @default.
- W2011043523 cites W2103001778 @default.
- W2011043523 cites W2107529466 @default.
- W2011043523 cites W2108106499 @default.
- W2011043523 cites W2110657098 @default.
- W2011043523 cites W2117152988 @default.
- W2011043523 cites W2119094401 @default.
- W2011043523 cites W2121563931 @default.
- W2011043523 cites W2121894027 @default.
- W2011043523 cites W2122302447 @default.
- W2011043523 cites W2122812102 @default.
- W2011043523 cites W2123440524 @default.
- W2011043523 cites W2123522154 @default.
- W2011043523 cites W2125287501 @default.
- W2011043523 cites W2128484647 @default.
- W2011043523 cites W2134498505 @default.
- W2011043523 cites W2135932038 @default.
- W2011043523 cites W2148471674 @default.
- W2011043523 cites W2150714767 @default.
- W2011043523 cites W2163183039 @default.
- W2011043523 cites W2163272120 @default.
- W2011043523 cites W2165727470 @default.
- W2011043523 cites W2165783384 @default.
- W2011043523 cites W2170319947 @default.
- W2011043523 cites W2172170716 @default.
- W2011043523 cites W2174903051 @default.
- W2011043523 cites W2312229443 @default.
- W2011043523 cites W2326532803 @default.
- W2011043523 cites W2340338748 @default.
- W2011043523 cites W4250389759 @default.
- W2011043523 cites W4255760236 @default.
- W2011043523 cites W4317926824 @default.
- W2011043523 doi "https://doi.org/10.1016/j.ceca.2014.08.012" @default.
- W2011043523 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25224502" @default.
- W2011043523 hasPublicationYear "2014" @default.
- W2011043523 type Work @default.
- W2011043523 sameAs 2011043523 @default.
- W2011043523 citedByCount "39" @default.
- W2011043523 countsByYear W20110435232014 @default.