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- W2011046511 abstract "Abstract Use of solid-phase synthesis for the derivatization of carboxylic acids with biotinylated spacers consisting of ethylenoxy units is described. An aminomethylated resin provided with an acid-labile aldehyde linker is used as the polymer support and three different systems with a reactive amino group are introduced. Acylation of each system was tested with a set of model carboxylic acids and afforded crude products of excellent purity. The preloaded resins are similar to the Biotin-PEG-NovaTagTM resin but offer several advantages including simple elongation of the spacer arm. The protocols described represent a very efficient way of modifying compounds to obtain ligands for affinity chromatography studies." @default.
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- W2011046511 date "2011-11-01" @default.
- W2011046511 modified "2023-09-27" @default.
- W2011046511 title "Novel preloaded resins for solid-phase biotinylation of carboxylic acids" @default.
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- W2011046511 doi "https://doi.org/10.1016/j.tetlet.2011.08.115" @default.
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