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- W2011047595 endingPage "686" @default.
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- W2011047595 abstract "Continued interest in the possible pathogenetic role of the SIA in diabetes mellitus has been perpetuated primarily by three observations: (1) that plasma and sera from many diabetic subjects and their close relatives contain higher levels of the SIA than most nondiabetics. (2) that the SIA appears to affect glucose metabolism of muscle but not adipose tissue, possibly accounting for the increased prevalence of obesity in adultonset diabetics; and (3) that the reduced B-chain of insulin when bound to albumin reproduces most of the in vitro and in vivo metabolic and physiochemical characteristics of the SIA. On the other hand, a critical appraisal of the present state of knowledge reveals serious obstacles to acceptance of a role for synalbumin in diabetes mellitus. These are: (1) the potential presence of a dialysis casing artifactual insulin antagonist; (2) the spectrum of antagonistic, neutral and stimulatory activity in albumin fractions prepared by methods not utilizing dialysis indicating that preparative technique can significantly affect the degree of measured insulin antagonism; (3) the failure of the SIA to demonstrate an unequivocal in-vivo effect; (4) a mechanism of action inconsistent with the metabolic alterations observed in diabetes mellitus; (5) the use of the relatively insensitive and imprecise rat hemidiaphragm bioassay to assess qualitative and quantitative differences in insulin antagonism; and (6) the lack of specificity since albumins of other species as well as egg albumin and gelatin are indistinguishable from the SIA in the assays currently in use. Although these difficulties do not absolutely deny a physiological role for the SIA, they do urge a very cautious interpretation of the available data until a much more selective means of assessment becomes possible." @default.
- W2011047595 created "2016-06-24" @default.
- W2011047595 creator A5049298087 @default.
- W2011047595 creator A5088864923 @default.
- W2011047595 date "1970-09-01" @default.
- W2011047595 modified "2023-09-27" @default.
- W2011047595 title "Role of synalbumin insulin antagonist in pathogenesis of diabetes mellitus" @default.
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