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- W2011051908 abstract "Abstract An optimum pH range, relatively narrow and close to physiological values, was found for both ouabain-sensitive and -insensitive saturable components of Rb+ influx in human red blood cells; the deviation of 1.5 units from that optimum resulted in about 75% inhibition in the maximum uptake, both in Na+-containing and Na+-free Mg2+ Ringer's solution. All changes in the ouabain-sensitive Rb+ influx were parallel to changes in the ouabain-senstive Rb+-activated Na+ efflux, suggesting that whereas the external H+ concentration influenced the rate of pumping it did not affect the Na+/Rb+(K+) coupling ratio. The apparent K m for all these fluxes increased as the pH went from the acid to the alkaline side; however, any speculation on the Rb+-site affinities and ionization constants is challenged by the complexity of these interactions. All observed effects were independent of the buffer used and all were reversible." @default.
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- W2011051908 date "1974-06-01" @default.
- W2011051908 modified "2023-09-27" @default.
- W2011051908 title "pH dependence of rubidium influx in human red blood cells" @default.
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- W2011051908 doi "https://doi.org/10.1016/0005-2736(74)90233-8" @default.
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