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- W2011052611 abstract "Focal cortical injuries generate various behavioral deficits associated with different morphological changes. The age and the area of the injury determine the nature and extent of recovery represented by the level of performance in various behavioral tasks. Previously, we have shown that motor cortex injury in early (but not late) adolescence leads to behavioral deficits that do not recover spontaneously with time. Considering the fact that the pace of brain maturation differs in different brain areas, we undertook to examine the pattern of spontaneous recovery following medial prefrontal cortex (mPFC) lesion in early or late adolescence. A battery of motor tasks (postural asymmetry, skilled reaching, sunflower seed manipulation, forepaw inhibition in swimming) was used to investigate the pattern of behavioral recovery following mPFC lesions. Golgi-Cox analysis was used to examine dendritic reorganization of the relevant brain areas. The results indicated that rats perform poorly when receiving mPFC injuries in late adolescence in contrast to when they receive the lesion in early adolescence. Almost opposite pattern of recovery following motor cortex and medial prefrontal injuries in early and late adolescence will be discussed as an age-area dependent model for prognosis of brain injury during adolescence." @default.
- W2011052611 created "2016-06-24" @default.
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- W2011052611 date "2012-04-01" @default.
- W2011052611 modified "2023-10-17" @default.
- W2011052611 title "Recovery from medial prefrontal cortex injury during adolescence: Implications for age-dependent plasticity" @default.
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- W2011052611 doi "https://doi.org/10.1016/j.bbr.2012.01.002" @default.
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