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- W2011053415 abstract "□ A series of substituted anilines was examined for radioprotective activity by injecting them ip into mice subjected to a near-lethal dose of 6 mV photons. Electronegative groups such as Br, NO2, CN, and acyl in the meta or para position gave rise to highly active compounds (80-100 % protection), while p-amino, methyl, amide, hydroxy, and fluoro groups decrease activity. No general correlations could be developed, however, between biological activity and a wide variety of calculated molecular parameters. The highest activity was found with p-amlnobenzophenone (1), p-aminopropiophenone (2), its ethylene ketal (3), 2-amino-5-chloropyridlne (35), and 5-amino-2- chloropyrldine (36). □ A series of substituted anilines was examined for radioprotective activity by injecting them ip into mice subjected to a near-lethal dose of 6 mV photons. Electronegative groups such as Br, NO2, CN, and acyl in the meta or para position gave rise to highly active compounds (80-100 % protection), while p-amino, methyl, amide, hydroxy, and fluoro groups decrease activity. No general correlations could be developed, however, between biological activity and a wide variety of calculated molecular parameters. The highest activity was found with p-amlnobenzophenone (1), p-aminopropiophenone (2), its ethylene ketal (3), 2-amino-5-chloropyridlne (35), and 5-amino-2- chloropyrldine (36)." @default.
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- W2011053415 date "1994-02-01" @default.
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- W2011053415 title "Potential Radioprotective Agents. 2. Substituted Anilines" @default.
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- W2011053415 doi "https://doi.org/10.1002/jps.2600830221" @default.
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