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- W2011054400 abstract "The transcription factor CCAAT/enhancer binding protein α (C/EBPα) is the DNA binding subunit of a multiprotein complex that regulates the pituitary-specific GH promoter. C/EBPα is absent from the GHFT1–5 pituitary progenitor cell line in which ectopic C/EBPα expression leads to activation of the otherwise dormant GH promoter. Transcriptional regulatory complexes are commonly envisaged as assembling from components that evenly diffuse throughout the nucleoplasm. We show that C/EBPα, expressed in GHFT1–5 cells as a fusion with color variants of the green fluorescent protein (GFP), concentrated specifically at peri-centromeric chromosomal domains. Although we found the CREB-binding protein (CBP) to activate C/EBPα-dependent transcription, CBP was absent from the pericentromeric chromatin. C/EBPα expression was accompanied by the translocation of endogenous and ectopically expressed CBP to pericentromeric chromatin. The intranuclear recruitment of CBP required the transcriptional activation domains of C/EBPα. C/EBPα also caused GFP-tagged TATA binding protein (TBP) to relocate to the Hoechst-stained domains. The altered intranuclear distribution of critical coregulatory factors defines complexes formed upon C/EBPα expression. It also identifies an organizational activity, which we label “intranuclear marshaling,” that may regulate gene expression by determining the cooperative and antagonistic interactions available at specific nuclear sites." @default.
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- W2011054400 date "2001-10-01" @default.
- W2011054400 modified "2023-09-27" @default.
- W2011054400 title "CCAAT/Enhancer Binding Protein α Assembles Essential Cooperating Factors in Common Subnuclear Domains" @default.
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- W2011054400 doi "https://doi.org/10.1210/mend.15.10.0716" @default.
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