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• W2011054586 abstract "Aniridic keratopathy is a major cause of vision loss in patients with aniridia. Penetrating keratoplasty has been proven ineffective for the long-term treatment of this disorder because it does not address the stem cell deficiency that is the primary etiologic factor. We evaluated the role of keratolimbal allograft (KLAL), a stem cell transplantation technique, for the treatment of patients with aniridic keratopathy.Retrospective noncomparative interventional case series.Thirty-one eyes of 23 patients with aniridic keratopathy.KLAL.Ocular surface stability, visual acuity, and success of subsequent penetrating or lamellar keratoplasty.Thirty-one eyes of 23 patients were treated with KLAL and followed up for 12 to 117 months (mean, 35.7 months). Twenty-three eyes (74.2%) achieved a stable ocular surface. Overall, the mean visual acuity improved from 20/1000 to 20/165. Twenty eyes (64.5%) underwent subsequent penetrating keratoplasty. Fourteen corneal transplant grafts (70.0%) were successful, and six (30.0%) failed. Nineteen (90.5%) of 21 eyes receiving systemic immunosuppression obtained a stable ocular surface, whereas only 4 (40.0%) of 10 eyes not receiving systemic immunosuppression achieved ocular surface stability (P < 0.01).KLAL is effective in treating aniridic keratopathy. Patients receiving systemic immunosuppression have a greater likelihood of achieving ocular surface stability and improved visual acuity compared with those who receive only topical immunosuppression." @default.
• W2011054586 created "2016-06-24" @default.
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• W2011054586 date "2003-01-01" @default.
• W2011054586 modified "2023-09-30" @default.
• W2011054586 title "Management of aniridic keratopathy with keratolimbal allograft: a limbal stem cell transplantation technique" @default.
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• W2011054586 doi "https://doi.org/10.1016/s0161-6420(02)01451-3" @default.
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