FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011056063> ?p ?o ?g. }

• W2011056063 endingPage "694" @default.
• W2011056063 startingPage "687" @default.
• W2011056063 abstract "An early and critical event in beta(2) integrin signalling during neutrophil adhesion is activation of Src tyrosine kinases and Syk. In the present study, we report Src kinase-dependent beta(2) integrin-induced tyrosine phosphorylation of Cbl occurring in parallel with increased Cbl-associated tyrosine kinase activity. These events concurred with activation of Fgr and, surprisingly, also with dissociation of this Src tyrosine kinase from Cbl. Moreover, the presence of the Src kinase inhibitor PP1 in an in vitro assay had only a limited effect on the Cbl-associated kinase activity. These results suggest that an additional active Src-dependent tyrosine kinase associates with Cbl. The following observations imply that Syk is such a kinase: (i) beta(2) integrins activated Syk in a Src-dependent manner, (ii) Syk was associated with Cbl much longer than Fgr was, and (iii) the Syk inhibitor piceatannol (3,4,3',5'-tetrahydroxy- trans -stilbene) abolished the Cbl-associated kinase activity in an in vitro assay. Effects of the mentioned interactions between these two kinases and Cbl may be related to the finding that Cbl is a ubiquitin E3 ligase. Indeed, we detected beta(2) integrin-induced ubiquitination of Fgr that, similar to the phosphorylation of Cbl, was abolished in cells pretreated with PP1. However, the ubiquitination of Fgr did not cause any apparent degradation of the protein. In contrast with Fgr, Syk was not modified by the E3 ligase. Thus Cbl appears to be essential in beta(2) integrin signalling, first by serving as a matrix for a subsequent agonist-induced signalling interaction between Fgr and Syk, and then by mediating ubiquitination of Fgr which possibly affects its interaction with Cbl." @default.
• W2011056063 created "2016-06-24" @default.
• W2011056063 creator A5020905101 @default.
• W2011056063 creator A5034713890 @default.
• W2011056063 creator A5082564504 @default.
• W2011056063 date "2003-03-01" @default.
• W2011056063 modified "2023-10-09" @default.
• W2011056063 title "Fgr but not Syk tyrosine kinase is a target for beta2 integrin-induced c-Cbl-mediated ubiquitination in adherent human neutrophils" @default.
• W2011056063 cites W1497941038 @default.
• W2011056063 cites W1498483050 @default.
• W2011056063 cites W1514135676 @default.
• W2011056063 cites W1571287379 @default.
• W2011056063 cites W1593056303 @default.
• W2011056063 cites W1704185171 @default.
• W2011056063 cites W1924609456 @default.
• W2011056063 cites W1979617068 @default.
• W2011056063 cites W1985749885 @default.
• W2011056063 cites W1989437563 @default.
• W2011056063 cites W2002475242 @default.
• W2011056063 cites W2008351137 @default.
• W2011056063 cites W2018434227 @default.
• W2011056063 cites W2027266132 @default.
• W2011056063 cites W2027533965 @default.
• W2011056063 cites W2033235597 @default.
• W2011056063 cites W2042116027 @default.
• W2011056063 cites W2046311950 @default.
• W2011056063 cites W2047517330 @default.
• W2011056063 cites W2050069950 @default.
• W2011056063 cites W2050428089 @default.
• W2011056063 cites W2059695583 @default.
• W2011056063 cites W2061921618 @default.
• W2011056063 cites W2065416929 @default.
• W2011056063 cites W2070672086 @default.
• W2011056063 cites W2077702220 @default.
• W2011056063 cites W2085248087 @default.
• W2011056063 cites W2088525733 @default.
• W2011056063 cites W2090895449 @default.
• W2011056063 cites W2091954771 @default.
• W2011056063 cites W2095467264 @default.
• W2011056063 cites W2095495579 @default.
• W2011056063 cites W2115136601 @default.
• W2011056063 cites W2119691249 @default.
• W2011056063 cites W2129941617 @default.
• W2011056063 cites W2150648024 @default.
• W2011056063 cites W2156480395 @default.
• W2011056063 cites W2157952919 @default.
• W2011056063 cites W2164241215 @default.
• W2011056063 cites W346614297 @default.
• W2011056063 doi "https://doi.org/10.1042/bj20021201" @default.
• W2011056063 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1223185" @default.
• W2011056063 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12435267" @default.
• W2011056063 hasPublicationYear "2003" @default.
• W2011056063 type Work @default.
• W2011056063 sameAs 2011056063 @default.
• W2011056063 citedByCount "13" @default.
• W2011056063 countsByYear W20110560632014 @default.
• W2011056063 countsByYear W20110560632015 @default.
• W2011056063 countsByYear W20110560632019 @default.
• W2011056063 crossrefType "journal-article" @default.
• W2011056063 hasAuthorship W2011056063A5020905101 @default.
• W2011056063 hasAuthorship W2011056063A5034713890 @default.
• W2011056063 hasAuthorship W2011056063A5082564504 @default.
• W2011056063 hasBestOaLocation W20110560632 @default.
• W2011056063 hasConcept C104317684 @default.
• W2011056063 hasConcept C108636557 @default.
• W2011056063 hasConcept C11960822 @default.
• W2011056063 hasConcept C134459356 @default.
• W2011056063 hasConcept C153911025 @default.
• W2011056063 hasConcept C184235292 @default.
• W2011056063 hasConcept C185592680 @default.
• W2011056063 hasConcept C25602115 @default.
• W2011056063 hasConcept C2776816829 @default.
• W2011056063 hasConcept C2777553839 @default.
• W2011056063 hasConcept C2779746291 @default.
• W2011056063 hasConcept C35174551 @default.
• W2011056063 hasConcept C42362537 @default.
• W2011056063 hasConcept C502942594 @default.
• W2011056063 hasConcept C55493867 @default.
• W2011056063 hasConcept C62478195 @default.
• W2011056063 hasConcept C86803240 @default.
• W2011056063 hasConcept C95444343 @default.
• W2011056063 hasConceptScore W2011056063C104317684 @default.
• W2011056063 hasConceptScore W2011056063C108636557 @default.
• W2011056063 hasConceptScore W2011056063C11960822 @default.
• W2011056063 hasConceptScore W2011056063C134459356 @default.
• W2011056063 hasConceptScore W2011056063C153911025 @default.
• W2011056063 hasConceptScore W2011056063C184235292 @default.
• W2011056063 hasConceptScore W2011056063C185592680 @default.
• W2011056063 hasConceptScore W2011056063C25602115 @default.
• W2011056063 hasConceptScore W2011056063C2776816829 @default.
• W2011056063 hasConceptScore W2011056063C2777553839 @default.
• W2011056063 hasConceptScore W2011056063C2779746291 @default.
• W2011056063 hasConceptScore W2011056063C35174551 @default.
• W2011056063 hasConceptScore W2011056063C42362537 @default.
• W2011056063 hasConceptScore W2011056063C502942594 @default.
• W2011056063 hasConceptScore W2011056063C55493867 @default.
• W2011056063 hasConceptScore W2011056063C62478195 @default.
• W2011056063 hasConceptScore W2011056063C86803240 @default.

• next