FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011056884> ?p ?o ?g. }

• W2011056884 endingPage "49" @default.
• W2011056884 startingPage "43" @default.
• W2011056884 abstract "PurposeData on the blood pharmacokinetics of vigabatrin, an antiepileptic drug with a unique and novel mechanism of action, in the rat are sparse. Additionally, little is known of the kinetics of vigabatrin in the central cerebrospinal fluid (CSF) compartment. We therefore investigated the rate of penetration into and the inter-relationship between serum and CSF compartments following systemic administration of vigabatrin in the rat.MethodsSprague–Dawley rats were implanted with a jugular vein catheter and a cisterna magna catheter for blood and CSF sampling, respectively. Vigabatrin was administered by intraperitonial injection at three different doses (250, 500 and 1000 mg/kg) and blood and CSF collected at timed intervals up to 8 h. Vigabatrin concentrations in sera and CSF were determined by high performance liquid chromatography.ResultsVigabatrin concentrations in blood and CSF rose linearly and dose-dependently and the time to maximum concentration (Tmax) was 0.4 and 1.0 h, respectively. Vigabatrin is not protein bound in serum and its elimination from serum (mean t1/2 values, 1.1–1.4 h) is rapid and dose-independent. The efflux of vigabatrin from CSF was significantly slower than that seen for serum (mean t1/2 values, 2.2–3.3 h).ConclusionsThe kinetics of vigabatrin are linear with rapid entry into CSF. However, although vigabatrin CSF kinetics parallel that seen in serum, CSF vigabatrin concentrations represent only 2% of concentrations seen in serum and do not reflect free drug concentrations in serum." @default.
• W2011056884 created "2016-06-24" @default.
• W2011056884 creator A5026136994 @default.
• W2011056884 creator A5029080737 @default.
• W2011056884 creator A5083062583 @default.
• W2011056884 date "2007-01-01" @default.
• W2011056884 modified "2023-10-11" @default.
• W2011056884 title "The pharmacokinetics of vigabatrin in rat blood and cerebrospinal fluid" @default.
• W2011056884 cites W1549394339 @default.
• W2011056884 cites W1936854893 @default.
• W2011056884 cites W1973680181 @default.
• W2011056884 cites W1977221546 @default.
• W2011056884 cites W1979491825 @default.
• W2011056884 cites W1988302543 @default.
• W2011056884 cites W1990837904 @default.
• W2011056884 cites W1991756815 @default.
• W2011056884 cites W1995844787 @default.
• W2011056884 cites W2001013519 @default.
• W2011056884 cites W2009432478 @default.
• W2011056884 cites W2014375175 @default.
• W2011056884 cites W2027689303 @default.
• W2011056884 cites W2027759517 @default.
• W2011056884 cites W2035352436 @default.
• W2011056884 cites W2041882230 @default.
• W2011056884 cites W2046786860 @default.
• W2011056884 cites W2049214932 @default.
• W2011056884 cites W2050910356 @default.
• W2011056884 cites W2060350237 @default.
• W2011056884 cites W2061465111 @default.
• W2011056884 cites W2066941852 @default.
• W2011056884 cites W2069134697 @default.
• W2011056884 cites W2081758626 @default.
• W2011056884 cites W2083563713 @default.
• W2011056884 cites W2085708319 @default.
• W2011056884 cites W2089921921 @default.
• W2011056884 cites W2106619039 @default.
• W2011056884 cites W2128065985 @default.
• W2011056884 cites W2138502200 @default.
• W2011056884 cites W2164892541 @default.
• W2011056884 cites W2334832378 @default.
• W2011056884 cites W4238087098 @default.
• W2011056884 doi "https://doi.org/10.1016/j.seizure.2006.10.003" @default.
• W2011056884 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17118677" @default.
• W2011056884 hasPublicationYear "2007" @default.
• W2011056884 type Work @default.
• W2011056884 sameAs 2011056884 @default.
• W2011056884 citedByCount "13" @default.
• W2011056884 countsByYear W20110568842013 @default.
• W2011056884 countsByYear W20110568842014 @default.
• W2011056884 countsByYear W20110568842020 @default.
• W2011056884 countsByYear W20110568842021 @default.
• W2011056884 crossrefType "journal-article" @default.
• W2011056884 hasAuthorship W2011056884A5026136994 @default.
• W2011056884 hasAuthorship W2011056884A5029080737 @default.
• W2011056884 hasAuthorship W2011056884A5083062583 @default.
• W2011056884 hasBestOaLocation W20110568841 @default.
• W2011056884 hasConcept C112705442 @default.
• W2011056884 hasConcept C118552586 @default.
• W2011056884 hasConcept C126322002 @default.
• W2011056884 hasConcept C134018914 @default.
• W2011056884 hasConcept C185592680 @default.
• W2011056884 hasConcept C2775858608 @default.
• W2011056884 hasConcept C2778186239 @default.
• W2011056884 hasConcept C2778200158 @default.
• W2011056884 hasConcept C2779651940 @default.
• W2011056884 hasConcept C2780837902 @default.
• W2011056884 hasConcept C71924100 @default.
• W2011056884 hasConcept C98274493 @default.
• W2011056884 hasConceptScore W2011056884C112705442 @default.
• W2011056884 hasConceptScore W2011056884C118552586 @default.
• W2011056884 hasConceptScore W2011056884C126322002 @default.
• W2011056884 hasConceptScore W2011056884C134018914 @default.
• W2011056884 hasConceptScore W2011056884C185592680 @default.
• W2011056884 hasConceptScore W2011056884C2775858608 @default.
• W2011056884 hasConceptScore W2011056884C2778186239 @default.
• W2011056884 hasConceptScore W2011056884C2778200158 @default.
• W2011056884 hasConceptScore W2011056884C2779651940 @default.
• W2011056884 hasConceptScore W2011056884C2780837902 @default.
• W2011056884 hasConceptScore W2011056884C71924100 @default.
• W2011056884 hasConceptScore W2011056884C98274493 @default.
• W2011056884 hasIssue "1" @default.
• W2011056884 hasLocation W20110568841 @default.
• W2011056884 hasLocation W20110568842 @default.
• W2011056884 hasOpenAccess W2011056884 @default.
• W2011056884 hasPrimaryLocation W20110568841 @default.
• W2011056884 hasRelatedWork W1964650076 @default.
• W2011056884 hasRelatedWork W2014329638 @default.
• W2011056884 hasRelatedWork W2015651815 @default.
• W2011056884 hasRelatedWork W2052463334 @default.
• W2011056884 hasRelatedWork W2093658095 @default.
• W2011056884 hasRelatedWork W2155854266 @default.
• W2011056884 hasRelatedWork W2748952813 @default.
• W2011056884 hasRelatedWork W4299845981 @default.
• W2011056884 hasRelatedWork W78605329 @default.
• W2011056884 hasRelatedWork W2067445788 @default.
• W2011056884 hasVolume "16" @default.
• W2011056884 isParatext "false" @default.
• W2011056884 isRetracted "false" @default.

• next