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• W2011056905 abstract "In this study, N-isopropylacrylamide (NIPAAm), propyl acrylic acid (PAAC), and poly(N-isopropylacrylamide-co-undecylenic acid) acrylamide were introduced to synthesize PNIPAAm-based nanogels (NG). The morphology of NG particles was characterized via transmission electron microscopy (TEM). The nanogels exhibited a lower critical solution temperature (LCST) of 34°C and a temperature-induced drug release in vitro. After conjugation of arginine-glycine-aspartic acid (RGD)–containing peptide (GRGDS), the cellular uptake of doxorubicin (Dox)-loaded nanogel by HeLa cells had been greatly enhanced. The Dox molecules in endocytosed nanogels could be released efficiently at 37°C and subsequently kill tumor cells, suggesting that the nanogel has great potential for targeting delivery." @default.
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• W2011056905 date "2015-01-06" @default.
• W2011056905 modified "2023-09-26" @default.
• W2011056905 title "Targeting of a Thermosensitive Nanogel Copolymerized With Macromonomer for Cell Uptake and Drug Controlled Release" @default.
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• W2011056905 doi "https://doi.org/10.1080/00914037.2014.958827" @default.
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