FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011057572> ?p ?o ?g. }

• W2011057572 endingPage "1871" @default.
• W2011057572 startingPage "1858" @default.
• W2011057572 abstract "Tight coupling between Ca(2+) channels and the sensor for vesicular transmitter release at the presynaptic active zone (AZ) is crucial for high-fidelity synaptic transmission. It has been hypothesized that a switch from a loosely coupled to a tightly coupled transmission mode is a common step in the maturation of CNS synapses. However, this hypothesis has never been tested at cortical synapses. We addressed this hypothesis at a representative small cortical synapse: the synapse connecting mouse cerebellar cortical parallel fibers to Purkinje neurons. We found that the slow Ca(2+) chelator EGTA affected release significantly stronger at immature than at mature synapses, while the fast chelator BAPTA was similarly effective in both groups. Analysis of paired-pulse ratios and quantification of release probability (pr) with multiple-probability fluctuation analysis revealed increased facilitation at immature synapses accompanied by reduced pr. Cav2.1 Ca(2+) channel immunoreactivity, assessed by quantitative high-resolution immuno-electron microscopy, was scattered over immature boutons but confined to putative AZs at mature boutons. Presynaptic Ca(2+) signals were quantified with two-photon microscopy and found to be similar between maturation stages. Models adjusted to fit EGTA dose-response curves as well as differential effects of the Ca(2+) channel blocker Cd(2+) indicate looser and less homogenous coupling at immature terminals compared with mature ones. These results demonstrate functionally relevant developmental tightening of influx-release coupling at a single AZ cortical synapse and corroborate developmental tightening of coupling as a prevalent phenomenon in the mammalian brain." @default.
• W2011057572 created "2016-06-24" @default.
• W2011057572 creator A5017811687 @default.
• W2011057572 creator A5019697934 @default.
• W2011057572 creator A5041279882 @default.
• W2011057572 creator A5058620157 @default.
• W2011057572 creator A5074700450 @default.
• W2011057572 creator A5076381637 @default.
• W2011057572 creator A5088285042 @default.
• W2011057572 date "2015-02-04" @default.
• W2011057572 modified "2023-10-14" @default.
• W2011057572 title "Developmental Tightening of Cerebellar Cortical Synaptic Influx-Release Coupling" @default.
• W2011057572 cites W1488181557 @default.
• W2011057572 cites W1493333082 @default.
• W2011057572 cites W1520756199 @default.
• W2011057572 cites W1560932778 @default.
• W2011057572 cites W1608821495 @default.
• W2011057572 cites W1670760110 @default.
• W2011057572 cites W1671421450 @default.
• W2011057572 cites W1877594537 @default.
• W2011057572 cites W1965893090 @default.
• W2011057572 cites W1974765629 @default.
• W2011057572 cites W1976435105 @default.
• W2011057572 cites W1978630448 @default.
• W2011057572 cites W1978936152 @default.
• W2011057572 cites W1989473290 @default.
• W2011057572 cites W1996618398 @default.
• W2011057572 cites W1998674325 @default.
• W2011057572 cites W2001319941 @default.
• W2011057572 cites W2002897495 @default.
• W2011057572 cites W2006184695 @default.
• W2011057572 cites W2007263885 @default.
• W2011057572 cites W2010905290 @default.
• W2011057572 cites W2011921884 @default.
• W2011057572 cites W2016880507 @default.
• W2011057572 cites W2017523889 @default.
• W2011057572 cites W2020602329 @default.
• W2011057572 cites W2021608570 @default.
• W2011057572 cites W2022286642 @default.
• W2011057572 cites W2025214550 @default.
• W2011057572 cites W2027565428 @default.
• W2011057572 cites W2028292571 @default.
• W2011057572 cites W2028789389 @default.
• W2011057572 cites W2031373742 @default.
• W2011057572 cites W2032943627 @default.
• W2011057572 cites W2033866317 @default.
• W2011057572 cites W2041733763 @default.
• W2011057572 cites W2042920344 @default.
• W2011057572 cites W2045546690 @default.
• W2011057572 cites W2045875535 @default.
• W2011057572 cites W2050878615 @default.
• W2011057572 cites W2053050328 @default.
• W2011057572 cites W2057012057 @default.
• W2011057572 cites W2057759105 @default.
• W2011057572 cites W2058022492 @default.
• W2011057572 cites W2064229854 @default.
• W2011057572 cites W2066182922 @default.
• W2011057572 cites W2067261761 @default.
• W2011057572 cites W2072747721 @default.
• W2011057572 cites W2074104271 @default.
• W2011057572 cites W2077910689 @default.
• W2011057572 cites W2082089816 @default.
• W2011057572 cites W2082144505 @default.
• W2011057572 cites W2087351063 @default.
• W2011057572 cites W2087648078 @default.
• W2011057572 cites W2090662268 @default.
• W2011057572 cites W2091694654 @default.
• W2011057572 cites W2091848186 @default.
• W2011057572 cites W2094314734 @default.
• W2011057572 cites W2095352259 @default.
• W2011057572 cites W2095938336 @default.
• W2011057572 cites W2102548112 @default.
• W2011057572 cites W2111260018 @default.
• W2011057572 cites W2112227347 @default.
• W2011057572 cites W2114219909 @default.
• W2011057572 cites W2115346246 @default.
• W2011057572 cites W2118271804 @default.
• W2011057572 cites W2122383890 @default.
• W2011057572 cites W2126722766 @default.
• W2011057572 cites W2129794085 @default.
• W2011057572 cites W2135414903 @default.
• W2011057572 cites W2138903675 @default.
• W2011057572 cites W2151526807 @default.
• W2011057572 cites W2153499119 @default.
• W2011057572 cites W2157572330 @default.
• W2011057572 cites W2169344023 @default.
• W2011057572 cites W2170612760 @default.
• W2011057572 cites W2171770411 @default.
• W2011057572 doi "https://doi.org/10.1523/jneurosci.2900-14.2015" @default.
• W2011057572 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6705354" @default.
• W2011057572 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25653347" @default.
• W2011057572 hasPublicationYear "2015" @default.
• W2011057572 type Work @default.
• W2011057572 sameAs 2011057572 @default.
• W2011057572 citedByCount "43" @default.
• W2011057572 countsByYear W20110575722015 @default.
• W2011057572 countsByYear W20110575722016 @default.
• W2011057572 countsByYear W20110575722017 @default.

• next