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- W2011058052 abstract "Atypical ductal hyperplasia (ADH), flat epithelial atypia (FEA), and lobular neoplasia (LN) form a group of early precursor lesions that are part of the low-grade pathway in breast cancer development. This concept implies that the neoplastic disease process begins at a stage much earlier than in situ carcinoma. We have performed a review of the published literature for the upgrade risk to ductal carcinoma in situ or invasive carcinoma in open biopsy after a diagnosis of ADH, FEA, or LN in core needle biopsy. This has revealed the highest upgrade risk for ADH (28.2% after open biopsy), followed by LN (14.9%), and FEA (10.2%). With LN, the pleomorphic subtype is believed to confer a higher risk than classical LN. With all types of precursor lesions, careful attention must be paid to the clinicopathological correlation for the guidance of the clinical management. Follow-up biopsies are generally indicated in ADH, and if there is any radiological-pathological discrepancy, also in LN or FEA." @default.
- W2011058052 created "2016-06-24" @default.
- W2011058052 creator A5002219591 @default.
- W2011058052 creator A5026134240 @default.
- W2011058052 creator A5074592491 @default.
- W2011058052 creator A5083483027 @default.
- W2011058052 date "2010-01-01" @default.
- W2011058052 modified "2023-10-17" @default.
- W2011058052 title "Early Breast Cancer Precursor Lesions: Lessons Learned from Molecular and Clinical Studies" @default.
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