FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011058076> ?p ?o ?g. }

• W2011058076 endingPage "972" @default.
• W2011058076 startingPage "964" @default.
• W2011058076 abstract "Pretreatment with dexamethasone (Dex) was not toxic for U937 cells but caused a rapid lethal response upon subsequent exposure to otherwise nontoxic concentrations of peroxynitrite. This effect was not associated with enhanced formation of hydrogen peroxide taking place after peroxynitrite and was shown previously to play a pivotal role in the ensuing lethal response. Further analyses revealed that although Dex did not affect cytosolic phospholipase A₂ (cPLA₂) expression, it markedly reduced the extent of arachidonic acid (AA) release mediated by peroxynitrite-dependent stimulation of cPLA₂. This event, as well as the enhanced toxicity, was abolished by mifepristone, a glucocorticoid receptor antagonist. The outcome of various approaches, using phospholipase A₂ inhibitors, cPLA₂ antisense oligonucleotide-transfected cells, and supplementation with exogenous AA, led to the demonstration that inhibition of cPLA₂ activity is causally linked to the increased susceptibility to peroxynitrite caused by Dex. Finally, the effects of Dex were shown to be mediated by enhanced expression of lipocortin 1 (LC1), a cPLA₂ inhibitory protein. These results indicate that Dex promotes toxicity in U937 cells exposed to otherwise nontoxic concentrations of peroxynitrite and that this event is causally linked to enhanced expression of LC1 leading to inhibition of cPLA₂. Thus, the increased lethal response arises because of LC1-dependent impairment of the AA-induced cytoprotective mechanism triggered by peroxynitrite." @default.
• W2011058076 created "2016-06-24" @default.
• W2011058076 creator A5024130549 @default.
• W2011058076 creator A5079220891 @default.
• W2011058076 date "2004-03-25" @default.
• W2011058076 modified "2023-10-10" @default.
• W2011058076 title "Dexamethasone Promotes Toxicity in U937 Cells Exposed to Otherwise Nontoxic Concentrations of Peroxynitrite: Pivotal Role for Lipocortin 1-Mediated Inhibition of Cytosolic Phospholipase A₂" @default.
• W2011058076 cites W122217056 @default.
• W2011058076 cites W1481381887 @default.
• W2011058076 cites W1484922293 @default.
• W2011058076 cites W1500094754 @default.
• W2011058076 cites W1500462989 @default.
• W2011058076 cites W1520725245 @default.
• W2011058076 cites W1865082605 @default.
• W2011058076 cites W1924092238 @default.
• W2011058076 cites W1963503573 @default.
• W2011058076 cites W1966247914 @default.
• W2011058076 cites W1966404503 @default.
• W2011058076 cites W1981705617 @default.
• W2011058076 cites W1982693549 @default.
• W2011058076 cites W1987401638 @default.
• W2011058076 cites W1999822120 @default.
• W2011058076 cites W2003332545 @default.
• W2011058076 cites W2003809475 @default.
• W2011058076 cites W2012397093 @default.
• W2011058076 cites W2017218685 @default.
• W2011058076 cites W2030033188 @default.
• W2011058076 cites W2030815114 @default.
• W2011058076 cites W2032676984 @default.
• W2011058076 cites W2033109378 @default.
• W2011058076 cites W2044535743 @default.
• W2011058076 cites W2045429393 @default.
• W2011058076 cites W2062597946 @default.
• W2011058076 cites W2064347448 @default.
• W2011058076 cites W2068146666 @default.
• W2011058076 cites W2074260405 @default.
• W2011058076 cites W2076279613 @default.
• W2011058076 cites W2093155471 @default.
• W2011058076 cites W2094340596 @default.
• W2011058076 cites W2101052664 @default.
• W2011058076 cites W2111381334 @default.
• W2011058076 cites W2132714580 @default.
• W2011058076 cites W2145803099 @default.
• W2011058076 cites W2320802058 @default.
• W2011058076 cites W4239595624 @default.
• W2011058076 cites W4241833478 @default.
• W2011058076 cites W4313335833 @default.
• W2011058076 doi "https://doi.org/10.1124/mol.65.4.964" @default.
• W2011058076 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15044626" @default.
• W2011058076 hasPublicationYear "2004" @default.
• W2011058076 type Work @default.
• W2011058076 sameAs 2011058076 @default.
• W2011058076 citedByCount "15" @default.
• W2011058076 countsByYear W20110580762012 @default.
• W2011058076 countsByYear W20110580762019 @default.
• W2011058076 countsByYear W20110580762022 @default.
• W2011058076 crossrefType "journal-article" @default.
• W2011058076 hasAuthorship W2011058076A5024130549 @default.
• W2011058076 hasAuthorship W2011058076A5079220891 @default.
• W2011058076 hasConcept C108634530 @default.
• W2011058076 hasConcept C126322002 @default.
• W2011058076 hasConcept C12927208 @default.
• W2011058076 hasConcept C134018914 @default.
• W2011058076 hasConcept C170493617 @default.
• W2011058076 hasConcept C181199279 @default.
• W2011058076 hasConcept C185592680 @default.
• W2011058076 hasConcept C190283241 @default.
• W2011058076 hasConcept C202751555 @default.
• W2011058076 hasConcept C2776551241 @default.
• W2011058076 hasConcept C2776888444 @default.
• W2011058076 hasConcept C2776989580 @default.
• W2011058076 hasConcept C2778784160 @default.
• W2011058076 hasConcept C2780004078 @default.
• W2011058076 hasConcept C2780795997 @default.
• W2011058076 hasConcept C29730261 @default.
• W2011058076 hasConcept C55493867 @default.
• W2011058076 hasConcept C59493245 @default.
• W2011058076 hasConcept C71924100 @default.
• W2011058076 hasConcept C86803240 @default.
• W2011058076 hasConcept C88634738 @default.
• W2011058076 hasConcept C98274493 @default.
• W2011058076 hasConceptScore W2011058076C108634530 @default.
• W2011058076 hasConceptScore W2011058076C126322002 @default.
• W2011058076 hasConceptScore W2011058076C12927208 @default.
• W2011058076 hasConceptScore W2011058076C134018914 @default.
• W2011058076 hasConceptScore W2011058076C170493617 @default.
• W2011058076 hasConceptScore W2011058076C181199279 @default.
• W2011058076 hasConceptScore W2011058076C185592680 @default.
• W2011058076 hasConceptScore W2011058076C190283241 @default.
• W2011058076 hasConceptScore W2011058076C202751555 @default.
• W2011058076 hasConceptScore W2011058076C2776551241 @default.
• W2011058076 hasConceptScore W2011058076C2776888444 @default.
• W2011058076 hasConceptScore W2011058076C2776989580 @default.
• W2011058076 hasConceptScore W2011058076C2778784160 @default.
• W2011058076 hasConceptScore W2011058076C2780004078 @default.
• W2011058076 hasConceptScore W2011058076C2780795997 @default.
• W2011058076 hasConceptScore W2011058076C29730261 @default.
• W2011058076 hasConceptScore W2011058076C55493867 @default.

• next