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• W2011058419 startingPage "193" @default.
• W2011058419 abstract "After excitotoxic lesion of the rat striatum, the time courses of local nerve growth factor (NGF) and NGF mRNA contents were investigated using a sensitive immunoassay (ELISA) and reverse transcription coupled to polymerase chain reaction (RT/PCR). To investigate a possible correlation of increased NGF expression and excitotoxin-induced reactive gliosis, striata were also analysed by immunohistochemistry with glial markers. We found elevated striatal NGF protein after lesion over the whole observation period. NGF mRNA showed a biphasic increase 10 h and 10 days after lesion, the latter co-inciding with an increased astrogliosis. These results indicate that NGF accumulation after excitotoxin-induced neurodegeneration is partly due to local reactive astrocytes." @default.
• W2011058419 created "2016-06-24" @default.
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• W2011058419 date "1994-02-01" @default.
• W2011058419 modified "2023-10-18" @default.
• W2011058419 title "Increased levels of nerve growth factor (NGF) protein and mRNA and reactive gliosis following kainic acid injection into the rat striatum" @default.
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• W2011058419 doi "https://doi.org/10.1016/0304-3940(94)90448-0" @default.
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