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• W2011059895 abstract "Members of the radical S ‐adenosylmethionine (AdoMet) superfamily reductively cleave AdoMet to generate the highly reactive 5′‐deoxyadenosyl radical (DOA) which initiates biological transformations by abstraction of a hydrogen atom. We demonstrate that three members of the family: biotin synthase (BioB), lipoyl synthase (LipA) and tyrosine lyase (ThiH) are inhibited in vitro by a combination of the products 5′‐deoxyadenosine (DOA) and methionine. These results suggest the observed inhibition is a common feature of the radical AdoMet proteins that form DOA and methionine as products. Addition of 5′‐methylthioadenosine/ S‐ adenosylhomocysteine nucleosidase (MTAN) to BioB, LipA or ThiH activity assays removed the product inhibition by catalysing the hydrolysis of DOA and gave an increase in activity." @default.
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• W2011059895 date "2009-03-26" @default.
• W2011059895 modified "2023-10-15" @default.
• W2011059895 title "Product inhibition in the radical<i>S</i>-adenosylmethionine family" @default.
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• W2011059895 doi "https://doi.org/10.1016/j.febslet.2009.03.044" @default.
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