Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011060894> ?p ?o ?g. }
- W2011060894 endingPage "1851" @default.
- W2011060894 startingPage "1844" @default.
- W2011060894 abstract "Background Cilostazol, a phosphodiesterase 3 inhibitor, is an antiplatelet drug that is widely used for preventing cardiovascular events, although, to date, there are few methods for evaluating its effects. Methods and Results Blood samples were taken at baseline and at 3 and 12 h in 10 healthy male subjects after 100 mg cilostazol intake. Each sample was examined by Western blot for phosphorylation levels of vasodilator-stimulated phosphoprotein (VASP), an abundant cAMP-dependent kinase substrate in platelets, and by the optical aggregometer for ADP- and collagen-induced aggregation, before and after 8 nmol/L prostaglandin E1 (PGE1) treatment. Cilostazol intake did not affect VASP phosphorylation levels or the maximal aggregation rates without PGE1 treatment. However, cilostazol intake apparently enhanced PGE1-induced VASP phosphorylation and PGE1-mediated reduction of ADP-and collagen-induced maximal aggregation rates. Levels of VASP phosphorylated at Ser157 were correlated and the maximal aggregation rates induced by ADP were inversely correlated with cilostazol concentrations in the plasma. Conclusion The antiplatelet effects of cilostazol intake could be evaluated by measuring VASP phosphorylation levels and maximal aggregation rates in platelets by ex vivo treatment with a low concentration of PGE1. (Circ J 2008; 72: 1844 - 1851)" @default.
- W2011060894 created "2016-06-24" @default.
- W2011060894 creator A5005788448 @default.
- W2011060894 creator A5009867090 @default.
- W2011060894 creator A5010363799 @default.
- W2011060894 creator A5016038172 @default.
- W2011060894 creator A5030864420 @default.
- W2011060894 creator A5060484333 @default.
- W2011060894 creator A5065164908 @default.
- W2011060894 creator A5065422848 @default.
- W2011060894 creator A5067306006 @default.
- W2011060894 creator A5080185082 @default.
- W2011060894 creator A5084166212 @default.
- W2011060894 creator A5088682387 @default.
- W2011060894 date "2008-01-01" @default.
- W2011060894 modified "2023-10-17" @default.
- W2011060894 title "Evaluation of the Antiplatelet Effects of Cilostazol, a Phosphodiesterase 3 Inhibitor, by VASP Phosphorylation and Platelet Aggregation" @default.
- W2011060894 cites W1878265155 @default.
- W2011060894 cites W1955963927 @default.
- W2011060894 cites W1975906565 @default.
- W2011060894 cites W1977736221 @default.
- W2011060894 cites W1981589156 @default.
- W2011060894 cites W1985089992 @default.
- W2011060894 cites W1985235031 @default.
- W2011060894 cites W1987972019 @default.
- W2011060894 cites W1989615944 @default.
- W2011060894 cites W1991201031 @default.
- W2011060894 cites W1992569957 @default.
- W2011060894 cites W1997251838 @default.
- W2011060894 cites W1997343401 @default.
- W2011060894 cites W2003746584 @default.
- W2011060894 cites W2024862370 @default.
- W2011060894 cites W2027484290 @default.
- W2011060894 cites W2034438272 @default.
- W2011060894 cites W2060063218 @default.
- W2011060894 cites W2069601667 @default.
- W2011060894 cites W2071415251 @default.
- W2011060894 cites W2079056347 @default.
- W2011060894 cites W2083658810 @default.
- W2011060894 cites W2100255765 @default.
- W2011060894 cites W2100837269 @default.
- W2011060894 cites W2104479866 @default.
- W2011060894 cites W2104539000 @default.
- W2011060894 cites W2119380659 @default.
- W2011060894 cites W2130350603 @default.
- W2011060894 cites W2144985796 @default.
- W2011060894 cites W2161114426 @default.
- W2011060894 cites W2171271044 @default.
- W2011060894 cites W249010743 @default.
- W2011060894 doi "https://doi.org/10.1253/circj.cj-08-0289" @default.
- W2011060894 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18832777" @default.
- W2011060894 hasPublicationYear "2008" @default.
- W2011060894 type Work @default.
- W2011060894 sameAs 2011060894 @default.
- W2011060894 citedByCount "23" @default.
- W2011060894 countsByYear W20110608942012 @default.
- W2011060894 countsByYear W20110608942014 @default.
- W2011060894 countsByYear W20110608942015 @default.
- W2011060894 countsByYear W20110608942016 @default.
- W2011060894 countsByYear W20110608942017 @default.
- W2011060894 countsByYear W20110608942018 @default.
- W2011060894 countsByYear W20110608942019 @default.
- W2011060894 countsByYear W20110608942020 @default.
- W2011060894 countsByYear W20110608942021 @default.
- W2011060894 countsByYear W20110608942022 @default.
- W2011060894 countsByYear W20110608942023 @default.
- W2011060894 crossrefType "journal-article" @default.
- W2011060894 hasAuthorship W2011060894A5005788448 @default.
- W2011060894 hasAuthorship W2011060894A5009867090 @default.
- W2011060894 hasAuthorship W2011060894A5010363799 @default.
- W2011060894 hasAuthorship W2011060894A5016038172 @default.
- W2011060894 hasAuthorship W2011060894A5030864420 @default.
- W2011060894 hasAuthorship W2011060894A5060484333 @default.
- W2011060894 hasAuthorship W2011060894A5065164908 @default.
- W2011060894 hasAuthorship W2011060894A5065422848 @default.
- W2011060894 hasAuthorship W2011060894A5067306006 @default.
- W2011060894 hasAuthorship W2011060894A5080185082 @default.
- W2011060894 hasAuthorship W2011060894A5084166212 @default.
- W2011060894 hasAuthorship W2011060894A5088682387 @default.
- W2011060894 hasBestOaLocation W20110608941 @default.
- W2011060894 hasConcept C11960822 @default.
- W2011060894 hasConcept C126322002 @default.
- W2011060894 hasConcept C134018914 @default.
- W2011060894 hasConcept C181199279 @default.
- W2011060894 hasConcept C185592680 @default.
- W2011060894 hasConcept C202751555 @default.
- W2011060894 hasConcept C26291073 @default.
- W2011060894 hasConcept C2776766087 @default.
- W2011060894 hasConcept C2777061661 @default.
- W2011060894 hasConcept C2777628954 @default.
- W2011060894 hasConcept C2779820409 @default.
- W2011060894 hasConcept C2779837120 @default.
- W2011060894 hasConcept C2909112448 @default.
- W2011060894 hasConcept C3018697912 @default.
- W2011060894 hasConcept C55493867 @default.
- W2011060894 hasConcept C58141971 @default.
- W2011060894 hasConcept C62826618 @default.
- W2011060894 hasConcept C71924100 @default.