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• W2011065462 abstract "Reactive oxygen species (ROS) are important regulatory molecules implicated in the signaling cascade triggered by tumor necrosis factor (TNF)alpha, although the events through which TNFalpha induces ROS generation are not well characterized. Here, we report that TNFalpha-induced ROS production was blocked by pretreatment with internalization inhibitor monodansyl cadaverine (MDC). Similarly, a transient expression of a GTP-binding and hydrolysis-defective dynamin mutant (dynamin(K44A)) that had been shown to be defective in internalization significantly attenuated the TNFalpha-induced intracellular ROS production. Importantly, the inhibition of receptor internalization suppressed TNFalpha signaling to mitogen-activated protein kinases (MAPKs) stimulation. Together, our results suggest that receptor internalization is somehow necessary for the TNFalpha-induced ROS generation and subsequent intracellular downstream signaling in non-phagocytes." @default.
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• W2011065462 date "2006-12-01" @default.
• W2011065462 modified "2023-09-27" @default.
• W2011065462 title "Inhibition of receptor internalization attenuates the TNFα-induced ROS generation in non-phagocytic cells" @default.
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• W2011065462 doi "https://doi.org/10.1016/j.bbrc.2006.10.154" @default.
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