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- W2011077733 abstract "Monocytic cytokine profiles of fifteen children with acute lymphoblastic leukaemia (ALL) were included to determine whether malignancy per se contributes to impaired cytokine profiles in vivo and ex vivo. The ex vivo tumour necrosis factor-α (TNF-α) and interleukin 1β (IL-1β) production was positively correlated with the monocyte number and with the number of intracellular TNF-α or IL-1β positive cells in lipopolysaccharide (LPS)-stimulated MNC cultures. The mean ex vivo TNF-α and IL-1β production per 1×104monocytes in these cultures was not significantly different in children at diagnosis of ALL, at remission or in controls. High IL-10 plasma levels at diagnosis of ALL had no effect on the ex vivo TNF-α and IL-1β production of monocytes in LPS stimulated MNC cultures. These results show that monocytes of ALL patients have a normal intrinsic capacity to produce cytokines ex vivo. However, the decreased monocyte number is responsible for the lower TNF-α and IL-1β concentrations ex vivo upon LPS stimulation." @default.
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- W2011077733 date "2000-11-01" @default.
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- W2011077733 title "INTRINSIC CAPACITY OF MONOCYTES TO PRODUCE CYTOKINES EX VIVO IN PATIENTS WITH ACUTE LYMPHOBLASTIC LEUKAEMIA" @default.
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- W2011077733 doi "https://doi.org/10.1006/cyto.2000.0776" @default.
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