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• W2011077782 abstract "In this paper, we present a micromachined film bulk acoustic resonator (FBAR) to detect protein-ligand interactions in real-time. The surface of the FBAR device has a thin layer of gold deposited on it to immobilize thiol-modified biotin. The resonant frequency of the biotin modified FBAR was measured to decrease by 170 ppm when exposed to streptavidin solution with a concentration of 5×10−7 M, corresponding to an added mass of 120 pg on the FBAR surface due to the biotin-streptavidin interaction. Consequently, the biotin modified FBAR can be used to observe in real time the biotin-streptavidin interaction without the use of labeling or molecular tags. The FBAR can be used in a variety of protein-ligand systems, and be designed for testing in array formats to give high throughput screening for drug discovery." @default.
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• W2011077782 date "2010-03-22" @default.
• W2011077782 modified "2023-09-27" @default.
• W2011077782 title "Label-free detection of protein-ligand interactions in real time using micromachined bulk acoustic resonators" @default.
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• W2011077782 doi "https://doi.org/10.1063/1.3358118" @default.
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