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- W2011078907 abstract "d-Tagatose is a low-calorie sweetener that tastes like sucrose. Its genotoxic potential was examined in five standard assays: the AmesSalmonella typhimuriumreverse mutation assay, theEscherichia coli/mammalian microsome assay, a chromosomal aberration assay in Chinese hamster ovary cells, a mouse lymphoma forward mutation assay, and anin vivomouse micronucleus assay.d-Tagatose was not found to increase the number of revertants per plate relative to vehicle controls in either theS. typhimuriumtester strains or the WP2uvrA− tester strain with or without metabolic activation at doses up to 5000 μg/plate. No significant increase in Chinese hamster ovary cells with chromosomal aberrations was observed at concentrations up to 5000 μg/ml with or without metabolic activation.d-Tagatose was not found to increase the mutant frequency in mouse lymphoma L5178Y cells with or without metabolic activation up to concentrations of 5000 μg/ml.d-Tagatose caused no significant increase in micronuclei in bone marrow polychromatic erythrocytes at doses up to 5000 mg/kg.d-Tagatose was not found to be genotoxic under the conditions of any of the assays described above." @default.
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- W2011078907 date "1999-04-01" @default.
- W2011078907 modified "2023-09-27" @default.
- W2011078907 title "Genotoxicity Tests ond-Tagatose" @default.
- W2011078907 doi "https://doi.org/10.1006/rtph.1998.1263" @default.
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