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• W2011078967 abstract "The purpose of this study was to investigate the plasma disposition kinetics of ceftriaxone in female camels (n = 5) following a single intravenous (i.v.) bolus or intramuscular (i.m.) injections at a dosage of 10 mg kg−1 body weight in all animals. A crossover design was carried out in two phases separated by 15 days. Jugular blood samples were collected serially for 48 h and the plasma was analysed by high-performance liquid chromatography (HPLC). Following single i.v. injections the plasma concentration time curves of ceftriaxone were best fitted to a two-compartment model. The drug was rapidly distributed with half-life of distribution t1/2α of 0.24 ± 0.01 h and moderately eliminated with elimination rate constant and elimination half-life of 0.27 ± 0.13 h−1 and 2.57 ± 0.52 h, respectively. The volume of distribution at steady state (Vdss) was 0.32 ± 0.01 l kg−1 and the total body clearance (Cltot) was 0.11 ± 0.01 l kg−1 h−1, respectively. Following i.m. administration, the mean Tmax, Cmax, t1/2el and AUC values for plasma data were 1.03 ± 0.23 h, 21.54 ± 2.61 μg ml−1, 1.76 ± 0.03 h and 85.82 ± 11.21 μg ml−1 h−1, respectively. The i.m. bioavailability was 93.42 ± 21.4% and the binding percentage of ceftriaxone to plasma protein was moderate, ranging from 33% to 42% with an average of 34.5%." @default.
• W2011078967 created "2016-06-24" @default.
• W2011078967 creator A5068580255 @default.
• W2011078967 date "2008-06-01" @default.
• W2011078967 modified "2023-10-18" @default.
• W2011078967 title "Pharmacokinetic parameters of ceftriaxone after single intravenous and intramuscular administration in camels (Camelus Dromedarius)" @default.
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• W2011078967 doi "https://doi.org/10.1016/j.rvsc.2007.07.005" @default.
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