FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011089631> ?p ?o ?g. }

• W2011089631 endingPage "e10310" @default.
• W2011089631 startingPage "e10310" @default.
• W2011089631 abstract "Transmissible agents involved in prion diseases differ in their capacities to target different regions of the central nervous system and lymphoid tissues, which are also host-dependent.Protease-resistant prion protein (PrP(res)) was analysed by Western blot in the spleen of transgenic mice (TgOvPrP4) that express the ovine prion protein under the control of the neuron-specific enolase promoter, after infection by intra-cerebral route with a variety of transmissible spongiform encephalopathies (TSEs) from cattle and small ruminants. Splenic PrP(res) was consistently detected in classical BSE and in most natural scrapie sources, the electrophoretic pattern showing similar features to that of cerebral PrP(res). However splenic PrP(res) was not detected in L-type BSE and TME-in-cattle, or in the CH1641 experimental scrapie isolate, indicating that some TSE strains showed reduced splenotropism in the ovine transgenic mice. In contrast with CH1641, PrP(res) was also consistently detected in the spleen of mice infected with six natural CH1641-like scrapie isolates, but then showed clearly different molecular features from those identified in the brains (unglycosylated PrP(res) at approximately 18 kDa with removal of the 12B2 epitope) of ovine transgenic mice or of sheep. These features included different cleavage of the main PrP(res) cleavage product (unglycosylated PrP(res) at approximately 19 kDa with preservation of the 12B2 epitope) and absence of the additional C-terminally cleaved PrP(res) product (unglycosylated form at approximately 14 kDa) that was detected in the brain.Studies in a transgenic mouse model expressing the sheep prion protein revealed different capacities of ruminant prions to propagate in the spleen. They showed unexpected features in CH1641-like ovine scrapie suggesting that such isolates contain mixed conformers with distinct capacities to propagate in the brain or lymphoid tissues of these mice." @default.
• W2011089631 created "2016-06-24" @default.
• W2011089631 creator A5040468965 @default.
• W2011089631 creator A5058559386 @default.
• W2011089631 creator A5085304984 @default.
• W2011089631 date "2010-04-26" @default.
• W2011089631 modified "2023-10-06" @default.
• W2011089631 title "Prions of Ruminants Show Distinct Splenotropisms in an Ovine Transgenic Mouse Model" @default.
• W2011089631 cites W1511522575 @default.
• W2011089631 cites W1540278447 @default.
• W2011089631 cites W1607679682 @default.
• W2011089631 cites W1976590712 @default.
• W2011089631 cites W1991237179 @default.
• W2011089631 cites W2000928261 @default.
• W2011089631 cites W2006427685 @default.
• W2011089631 cites W2011574202 @default.
• W2011089631 cites W2013575731 @default.
• W2011089631 cites W2017092523 @default.
• W2011089631 cites W2022614447 @default.
• W2011089631 cites W2023904661 @default.
• W2011089631 cites W2026244014 @default.
• W2011089631 cites W2032952473 @default.
• W2011089631 cites W2052107975 @default.
• W2011089631 cites W2060129054 @default.
• W2011089631 cites W2064898026 @default.
• W2011089631 cites W2066113001 @default.
• W2011089631 cites W2068826304 @default.
• W2011089631 cites W2071117570 @default.
• W2011089631 cites W2073436285 @default.
• W2011089631 cites W2077455131 @default.
• W2011089631 cites W2086169382 @default.
• W2011089631 cites W2092121728 @default.
• W2011089631 cites W2098021716 @default.
• W2011089631 cites W2098103936 @default.
• W2011089631 cites W2110458251 @default.
• W2011089631 cites W2117380355 @default.
• W2011089631 cites W2119861236 @default.
• W2011089631 cites W2126655133 @default.
• W2011089631 cites W2130432938 @default.
• W2011089631 cites W2137802088 @default.
• W2011089631 cites W2140416160 @default.
• W2011089631 cites W2142880647 @default.
• W2011089631 cites W2143358380 @default.
• W2011089631 cites W2156023394 @default.
• W2011089631 cites W2169074095 @default.
• W2011089631 cites W2169109742 @default.
• W2011089631 cites W2172010518 @default.
• W2011089631 cites W2261386015 @default.
• W2011089631 cites W2324660492 @default.
• W2011089631 doi "https://doi.org/10.1371/journal.pone.0010310" @default.
• W2011089631 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2859945" @default.
• W2011089631 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20436680" @default.
• W2011089631 hasPublicationYear "2010" @default.
• W2011089631 type Work @default.
• W2011089631 sameAs 2011089631 @default.
• W2011089631 citedByCount "12" @default.
• W2011089631 countsByYear W20110896312012 @default.
• W2011089631 countsByYear W20110896312013 @default.
• W2011089631 countsByYear W20110896312014 @default.
• W2011089631 countsByYear W20110896312018 @default.
• W2011089631 countsByYear W20110896312019 @default.
• W2011089631 countsByYear W20110896312020 @default.
• W2011089631 crossrefType "journal-article" @default.
• W2011089631 hasAuthorship W2011089631A5040468965 @default.
• W2011089631 hasAuthorship W2011089631A5058559386 @default.
• W2011089631 hasAuthorship W2011089631A5085304984 @default.
• W2011089631 hasBestOaLocation W20110896311 @default.
• W2011089631 hasConcept C102230213 @default.
• W2011089631 hasConcept C104317684 @default.
• W2011089631 hasConcept C141035611 @default.
• W2011089631 hasConcept C142724271 @default.
• W2011089631 hasConcept C153911025 @default.
• W2011089631 hasConcept C159047783 @default.
• W2011089631 hasConcept C159654299 @default.
• W2011089631 hasConcept C195616568 @default.
• W2011089631 hasConcept C203014093 @default.
• W2011089631 hasConcept C2776415932 @default.
• W2011089631 hasConcept C2776735649 @default.
• W2011089631 hasConcept C2776797465 @default.
• W2011089631 hasConcept C2779134260 @default.
• W2011089631 hasConcept C2780931953 @default.
• W2011089631 hasConcept C3019804061 @default.
• W2011089631 hasConcept C55493867 @default.
• W2011089631 hasConcept C71924100 @default.
• W2011089631 hasConcept C86803240 @default.
• W2011089631 hasConceptScore W2011089631C102230213 @default.
• W2011089631 hasConceptScore W2011089631C104317684 @default.
• W2011089631 hasConceptScore W2011089631C141035611 @default.
• W2011089631 hasConceptScore W2011089631C142724271 @default.
• W2011089631 hasConceptScore W2011089631C153911025 @default.
• W2011089631 hasConceptScore W2011089631C159047783 @default.
• W2011089631 hasConceptScore W2011089631C159654299 @default.
• W2011089631 hasConceptScore W2011089631C195616568 @default.
• W2011089631 hasConceptScore W2011089631C203014093 @default.
• W2011089631 hasConceptScore W2011089631C2776415932 @default.
• W2011089631 hasConceptScore W2011089631C2776735649 @default.
• W2011089631 hasConceptScore W2011089631C2776797465 @default.
• W2011089631 hasConceptScore W2011089631C2779134260 @default.

• next