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• W2011092300 abstract "Background: Relapsed disease remains a major obstacle following autologous hematopoietic stem cell transplantation (HSCT) for non-Hodgkin's lymphoma (NHL) and multiple myeloma (MM). Studies regarding the role of residual tumour cells collected in autografts in earlier relapse and reduced survival have been inconclusive. The impact of residual disease detected by sensitive molecular methods in autologous PBPCs remains uncertain and is addressed in this study. Methods: Patients undergoing autologous HSCT for NHL and MM at our institution between June 2001 and January 2006 were enrolled (n = 158). Aliquots of freshly collected PBPC collections were assessed for the presence of clonal IgH gene rearrangements using qualitative semi-nested PCR. Patients with detectable clonal IgH gene rearrangements were designated “positive” and compared with “negative” patients without detectable IgH gene rearrangements. Survival, progression-free survival, and time to next treatment were determined for all patients. All outcomes were compared using the method of Kaplan and Meier. Results: In comparison to patients with “positive” PBPC grafts, patients “negative” for detectable disease had no improvement in overall survival for MM (p = 0.91) and for NHL (p = 0.82). Further analysis based on tissue histology in patients with NHL revealed no significant difference in overall survival between patients with “positive” grafts compared with “negative” PBPC collections (aggressive histology NHL, p = 0.74; indolent NHL, p = 0.29). There was also no significant improvement in progression-free survival among patients with NHL (p = 0.85) or MM (p = 0.91). Conclusion: The use of autologous PBPCs “negative” for contaminating tumour cells does not lead to improved overall survival in MM or NHL. Furthermore, the absence of detectable clonal IgH rearrangements using sensitive PCR did not correlate with a reduction in progression-free survival. Our results suggest that disease relapse cannot be adequately explained by the reinfusion of PBPCs containing residual tumour cells. It is possible that high dose chemotherapy regimens used in autologous HSCT are not sufficiently eliminating residual tumour burden in some patients, including those with “negative” PBPC collections. Taken together, our results suggest that strategies aimed at removing tumour cells from autologous PBPC grafts in patients with MM and NHL may have marginal benefit." @default.
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• W2011092300 date "2008-02-01" @default.
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• W2011092300 title "109: IgH Gene Rearrangements in PBPC Mononuclear Cells does not Influence Survival or Relapse following Autologous Transplantation for B-cell Lymphoproliferative Diseases" @default.
• W2011092300 doi "https://doi.org/10.1016/j.bbmt.2007.12.118" @default.
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