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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011104583> ?p ?o ?g. }

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• W2011104583 abstract "The epidermal growth factor receptor (EGFR) is widely expressed in advanced colorectal cancers (CRCs), and higher levels of EGFR are inversely related to survival in these patients. Two general strategies have been used to block EGFR signaling: preventing ligand binding with anti-EGFR monoclonal antibodies (eg, cetuximab and ABX-EGF) and inhibiting its intrinsic tyrosine kinase with small molecules (eg, gefitinib [Iressa] and erlotinib [OSI-774,Tarceva]). Phase II trials of cetuximab suggest that it might be an effective treatment option alone or in combination with standard therapies as first- or second-line therapy. Phase I studies evaluating other EGFR inhibitors in patients with CRC have been reported. The inclusion of anti-EGFR therapies into standard treatment is the subject of current clinical trials." @default.
• W2011104583 created "2016-06-24" @default.
• W2011104583 creator A5015582820 @default.
• W2011104583 date "2003-02-01" @default.
• W2011104583 modified "2023-10-14" @default.
• W2011104583 title "Epidermal Growth Factor Receptor as a Therapeutic Target in Colorectal Cancer" @default.
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• W2011104583 doi "https://doi.org/10.3816/ccc.2003.n.006" @default.
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