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- W2011106109 abstract "The identification of selective constraints impeding the adaptive evolution of macromolecules and metabolic systems is compared between the two most prevalent approaches to the study of biochemical adaptation. Constraints discerned from the interspecific comparative method address the features of enzymes that are conserved across evolutionary lineages; constraints determined from the evolutionary genetic approach involve factors that interfere with the ability of natural selection to direct the adaptive process. Difficulties associated with the constraints identified by the comparative method are examined. These are shown to arise from the lack of an adequate definition of molecular adaptedness and from the confounding effects of factors that may act to constrain the process of biochemical adaptation. Constraints on this genetic process of biochemical adaptation are discussed at three levels of biological organization: populations, multienzyme pathways, and individual enzymes embedded within these pathways. A model is presented that allows for adaptive change in any pathway enzyme irrespective of its role in determining system flux." @default.
- W2011106109 created "2016-06-24" @default.
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- W2011106109 date "1988-05-01" @default.
- W2011106109 modified "2023-10-18" @default.
- W2011106109 title "Constraints on the genetic process of biochemical adaptation" @default.
- W2011106109 doi "https://doi.org/10.1139/z88-166" @default.
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