FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011106479> ?p ?o ?g. }

• W2011106479 endingPage "1003" @default.
• W2011106479 startingPage "997" @default.
• W2011106479 abstract "Upregulation of transforming growth factor-β (TGF-β) signaling is interrelated with the development of airway remodeling. In this study, we examined the role of two E3 ubiquitin ligases, Arkadia and Smurf2, which are critically required for TGF-β signaling in airway remodeling. Rats were immunized with ovalbumin (OVA) and then challenged with an OVA aerosol. In in vitro experiments, normal human bronchial epithelial cells were stimulated with TGF-β1 with or without the preincubation of Arkadia/Smurf2 small interfering RNA (siRNA) or lactacystin (an inhibitor of proteasomal degradation). In the lungs of OVA-treated rats, a large number of inflammatory cells were present near the airways. An increased subepithelial collagen deposition was associated with high expression levels of Smad7, SnoN and Ski mRNAs, Arkadia, Smurf2, and TGF-β type I receptor (TβRI), but low expression levels of Smad7, SnoN and Ski proteins. Smad7, SnoN and Ski interacted with both Arkadia and Smurf2 while TβRI only interacted with Smurf2 but not with Arkadia. In in vitro experiments, the inhibitory effect of TGF-β1 on the expression of Smad7, SnoN and Ski was reversed by Arkadia siRNA and lactacystin, whereas the stimulatory effect of TGF-β1 on the expression of TβRI protein and Smad7/SnoN/Ski mRNAs was not affected. In contrast, Smurf2 siRNA did not influence the effects of TGF-β1 on the expression of the above proteins. Our results suggest that Arkadia may contribute to the pathogenesis of airway remodeling through enhancing TGF-β signaling by inducing the reduction of Smad7, SnoN and Ski proteins in OVA-sensitized and -challenged rats." @default.
• W2011106479 created "2016-06-24" @default.
• W2011106479 creator A5001642071 @default.
• W2011106479 creator A5004788351 @default.
• W2011106479 creator A5023763518 @default.
• W2011106479 creator A5029481246 @default.
• W2011106479 creator A5046650650 @default.
• W2011106479 creator A5067152089 @default.
• W2011106479 date "2010-07-01" @default.
• W2011106479 modified "2023-09-28" @default.
• W2011106479 title "Effects of Arkadia on airway remodeling through enhancing TGF-β signaling in allergic rats" @default.
• W2011106479 cites W1599467641 @default.
• W2011106479 cites W1965344790 @default.
• W2011106479 cites W1971129021 @default.
• W2011106479 cites W1979528064 @default.
• W2011106479 cites W1981853558 @default.
• W2011106479 cites W1988810849 @default.
• W2011106479 cites W1995492033 @default.
• W2011106479 cites W2009396278 @default.
• W2011106479 cites W2016789558 @default.
• W2011106479 cites W2021755901 @default.
• W2011106479 cites W2029930661 @default.
• W2011106479 cites W2036708397 @default.
• W2011106479 cites W2058278041 @default.
• W2011106479 cites W2059392211 @default.
• W2011106479 cites W2065633653 @default.
• W2011106479 cites W2082050214 @default.
• W2011106479 cites W2091620221 @default.
• W2011106479 cites W2092344861 @default.
• W2011106479 cites W2102784194 @default.
• W2011106479 cites W2108904800 @default.
• W2011106479 cites W2116053081 @default.
• W2011106479 cites W2118676765 @default.
• W2011106479 cites W2124350477 @default.
• W2011106479 cites W2135856878 @default.
• W2011106479 cites W2142278869 @default.
• W2011106479 cites W2154619356 @default.
• W2011106479 cites W2162291763 @default.
• W2011106479 doi "https://doi.org/10.1038/labinvest.2010.78" @default.
• W2011106479 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20386537" @default.
• W2011106479 hasPublicationYear "2010" @default.
• W2011106479 type Work @default.
• W2011106479 sameAs 2011106479 @default.
• W2011106479 citedByCount "8" @default.
• W2011106479 countsByYear W20111064792012 @default.
• W2011106479 countsByYear W20111064792014 @default.
• W2011106479 countsByYear W20111064792016 @default.
• W2011106479 countsByYear W20111064792017 @default.
• W2011106479 countsByYear W20111064792018 @default.
• W2011106479 countsByYear W20111064792020 @default.
• W2011106479 countsByYear W20111064792021 @default.
• W2011106479 crossrefType "journal-article" @default.
• W2011106479 hasAuthorship W2011106479A5001642071 @default.
• W2011106479 hasAuthorship W2011106479A5004788351 @default.
• W2011106479 hasAuthorship W2011106479A5023763518 @default.
• W2011106479 hasAuthorship W2011106479A5029481246 @default.
• W2011106479 hasAuthorship W2011106479A5046650650 @default.
• W2011106479 hasAuthorship W2011106479A5067152089 @default.
• W2011106479 hasBestOaLocation W20111064791 @default.
• W2011106479 hasConcept C104317684 @default.
• W2011106479 hasConcept C118131993 @default.
• W2011106479 hasConcept C127561419 @default.
• W2011106479 hasConcept C185592680 @default.
• W2011106479 hasConcept C203014093 @default.
• W2011106479 hasConcept C22615655 @default.
• W2011106479 hasConcept C25602115 @default.
• W2011106479 hasConcept C27740335 @default.
• W2011106479 hasConcept C2776148510 @default.
• W2011106479 hasConcept C2776946954 @default.
• W2011106479 hasConcept C2778367456 @default.
• W2011106479 hasConcept C55493867 @default.
• W2011106479 hasConcept C62478195 @default.
• W2011106479 hasConcept C67705224 @default.
• W2011106479 hasConcept C86803240 @default.
• W2011106479 hasConcept C8891405 @default.
• W2011106479 hasConcept C95444343 @default.
• W2011106479 hasConceptScore W2011106479C104317684 @default.
• W2011106479 hasConceptScore W2011106479C118131993 @default.
• W2011106479 hasConceptScore W2011106479C127561419 @default.
• W2011106479 hasConceptScore W2011106479C185592680 @default.
• W2011106479 hasConceptScore W2011106479C203014093 @default.
• W2011106479 hasConceptScore W2011106479C22615655 @default.
• W2011106479 hasConceptScore W2011106479C25602115 @default.
• W2011106479 hasConceptScore W2011106479C27740335 @default.
• W2011106479 hasConceptScore W2011106479C2776148510 @default.
• W2011106479 hasConceptScore W2011106479C2776946954 @default.
• W2011106479 hasConceptScore W2011106479C2778367456 @default.
• W2011106479 hasConceptScore W2011106479C55493867 @default.
• W2011106479 hasConceptScore W2011106479C62478195 @default.
• W2011106479 hasConceptScore W2011106479C67705224 @default.
• W2011106479 hasConceptScore W2011106479C86803240 @default.
• W2011106479 hasConceptScore W2011106479C8891405 @default.
• W2011106479 hasConceptScore W2011106479C95444343 @default.
• W2011106479 hasIssue "7" @default.
• W2011106479 hasLocation W20111064791 @default.
• W2011106479 hasLocation W20111064792 @default.
• W2011106479 hasOpenAccess W2011106479 @default.
• W2011106479 hasPrimaryLocation W20111064791 @default.

• next