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- W2011109758 abstract "The 3beta-hydroxysteroid dehydrogenase (3beta-HSD) isoenzymes play a key role in cellular steroid hormone synthesis. Here, a 3beta-HSD gene homolog was cloned from Rana grylio virus (RGV), a member of family Iridoviridae. RGV 3beta-HSD gene has 1068bp, encoding a 355aa predicted protein. Transcription analyses showed that RGV 3beta-HSD gene was transcribed immediate-early during infection from an initiation site 19 nucleotides upstream of the translation start site. Confocal microscopy revealed that the 3beta-HSD-EGFP fusion protein was exclusively colocalized with the mitochondria marker (pDsRed2-Mito) in EPC cells. Upon morphological observation and MTT assay, it was revealed that overexpression of RGV 3beta-HSD in EPC cells could apparently suppress RGV-induced cytopathic effect (CPE). The present studies indicate that the RGV immediate-early 3beta-HSD gene encodes a mitochondria-localized protein, which has a novel role in suppressing virus-induced CPE. All these suggest that RGV 3beta-HSD might be a protein involved in host-virus interaction." @default.
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- W2011109758 date "2006-12-01" @default.
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- W2011109758 title "Characterization of the Rana grylio virus 3β-hydroxysteroid dehydrogenase and its novel role in suppressing virus-induced cytopathic effect" @default.
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- W2011109758 doi "https://doi.org/10.1016/j.bbrc.2006.09.169" @default.
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