Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011112821> ?p ?o ?g. }
Showing items 1 to 57 of
57
with 100 items per page.
- W2011112821 endingPage "483" @default.
- W2011112821 startingPage "479" @default.
- W2011112821 abstract "Once daily administration of the 24 hour diphenylhydantoin anticonvulsant requirement was studied in children. Each patient served as his own control by means of a crossover design. Comparison between the single and divided dose schedules failed to reveal any clinically significant differences in seizure control or drug-related toxicity. Serum levels were remarkably uniform for each patient regardless of whether the drug was administered three times per day or all at one time. No evidence of excessive drug accumulation occurred at the time of peak absorption following single daily administration. Levels obtained 24 hours after administration of the dosage were the same as those at 12 hours, indicating no tendency for subtherapeutic levels just prior to the next dose. A dose of 5 mg. per kilogram per day of diphenylhydantoin generally will produce serum concentrations of 10 μg per milliliter. The potential advantages of single daily administration are: reduced hospital nursing costs, patient convenience, and improved seizure control due to better reliability. The single daily dose must not be inadvertently forgotten." @default.
- W2011112821 created "2016-06-24" @default.
- W2011112821 creator A5001369831 @default.
- W2011112821 creator A5024648570 @default.
- W2011112821 creator A5034827618 @default.
- W2011112821 creator A5049401955 @default.
- W2011112821 date "1973-09-01" @default.
- W2011112821 modified "2023-10-14" @default.
- W2011112821 title "Single daily dose of diphenylhydantoin in children" @default.
- W2011112821 cites W1943451672 @default.
- W2011112821 cites W1972844115 @default.
- W2011112821 cites W2034995455 @default.
- W2011112821 cites W2060227584 @default.
- W2011112821 cites W2074930129 @default.
- W2011112821 cites W2075686154 @default.
- W2011112821 cites W2082339305 @default.
- W2011112821 cites W2094674441 @default.
- W2011112821 cites W2326909610 @default.
- W2011112821 cites W2333891154 @default.
- W2011112821 cites W4240407292 @default.
- W2011112821 doi "https://doi.org/10.1016/s0022-3476(73)80281-1" @default.
- W2011112821 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4725154" @default.
- W2011112821 hasPublicationYear "1973" @default.
- W2011112821 type Work @default.
- W2011112821 sameAs 2011112821 @default.
- W2011112821 citedByCount "10" @default.
- W2011112821 crossrefType "journal-article" @default.
- W2011112821 hasAuthorship W2011112821A5001369831 @default.
- W2011112821 hasAuthorship W2011112821A5024648570 @default.
- W2011112821 hasAuthorship W2011112821A5034827618 @default.
- W2011112821 hasAuthorship W2011112821A5049401955 @default.
- W2011112821 hasConcept C71924100 @default.
- W2011112821 hasConcept C98274493 @default.
- W2011112821 hasConceptScore W2011112821C71924100 @default.
- W2011112821 hasConceptScore W2011112821C98274493 @default.
- W2011112821 hasIssue "3" @default.
- W2011112821 hasLocation W20111128211 @default.
- W2011112821 hasLocation W20111128212 @default.
- W2011112821 hasOpenAccess W2011112821 @default.
- W2011112821 hasPrimaryLocation W20111128211 @default.
- W2011112821 hasRelatedWork W1489783725 @default.
- W2011112821 hasRelatedWork W1506200166 @default.
- W2011112821 hasRelatedWork W2039318446 @default.
- W2011112821 hasRelatedWork W2048182022 @default.
- W2011112821 hasRelatedWork W2080531066 @default.
- W2011112821 hasRelatedWork W2604872355 @default.
- W2011112821 hasRelatedWork W2748952813 @default.
- W2011112821 hasRelatedWork W2899084033 @default.
- W2011112821 hasRelatedWork W3032375762 @default.
- W2011112821 hasRelatedWork W3108674512 @default.
- W2011112821 hasVolume "83" @default.
- W2011112821 isParatext "false" @default.
- W2011112821 isRetracted "false" @default.
- W2011112821 magId "2011112821" @default.
- W2011112821 workType "article" @default.