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• W2011113611 endingPage "330" @default.
• W2011113611 startingPage "319" @default.
• W2011113611 abstract "Changes in lipid peroxidation, lipofuscin concentration, and multiple unit activity (MUA recorded in conscious animals) in the CA3 region were studied in the hippocampus of male Wistar rats aged 4, 8, 16, and 24 months. The lipid peroxidation and lipofuscin concentration were increased with age. The MUA, however, declined with age. Correlational analyses were performed for the four age groups to determine the relationship between the age-associated decline in MUA with the age-related alterations in lipid peroxidation and lipofuscin concentrations. The age-related increase in lipid peroxidation correlated positively with the age-associated increase in lipofuscin concentration. The age-related increases in lipid peroxidation and lipofuscin concentration correlated negatively with the changes in MUA. Since lipid peroxidation may affect neuronal electrophysiology, our data suggested that age-related increase in lipid peroxidation may contribute to an age-associated decline in neuronal electrical activity. Centrophenoxine effects were studied on the three above-mentioned age-associated changes in the hippocampus. The drug had no effect on all three parameters in 4- and 8-month-old rats. In 16- and 24-month-old rats, however, the drug significantly increased the MUA but concomitantly decreased lipofuscin concentration and lipid peroxidation. Correlational analyses of the data on MUA, lipid peroxidation and lipofuscin concentration from the centrophenoxine-treated animals showed that the drug-induced diminution in both lipofuscin and lipid peroxidation was significantly correlated with the drug-induced increase in MUA. The differential effect of the drug in younger (4-8 months) and older (16-24 months) animals indicated that the stimulation of MUA was clearly associated with concomitant decrease in lipid peroxidation and lipofuscin concentration." @default.
• W2011113611 created "2016-06-24" @default.
• W2011113611 creator A5056083815 @default.
• W2011113611 creator A5068385740 @default.
• W2011113611 creator A5088459668 @default.
• W2011113611 date "1993-07-01" @default.
• W2011113611 modified "2023-10-01" @default.
• W2011113611 title "Age-related decline in multiple unit action potentials of ca3 region of rat hippocampus: Correlation with lipid peroxidation and lipofuscin concentration and the effect of centrophenoxine" @default.
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• W2011113611 doi "https://doi.org/10.1016/0197-4580(93)90117-t" @default.
• W2011113611 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8367013" @default.
• W2011113611 hasPublicationYear "1993" @default.
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