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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011120216> ?p ?o ?g. }

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• W2011120216 abstract "Phosphorylation of the P proteins of nonsegmented negative-strand RNA viruses is critical for their function as transactivators of the viral RNA polymerases. Using unphosphorylated P protein of human parainfluenza virus type 3 (HPIV3) expressed in Escherichia coli, we have shown that the cellular protein kinase that phosphorylates P in vitro is biochemically and immunologically indistinguishable from cellular protein kinase C isoform zeta (PKC-zeta). Further, PKC-zeta is specifically packaged within the progeny HPIV3 virions and remains tightly associated with the ribonucleoprotein complex. The P protein seems also to be phosphorylated intracellularly by PKC-zeta, as shown by the similar protease digestion pattern of the in vitro and in vivo phosphorylated P proteins. The growth of HPIV3 in CV-1 cells is completely abrogated when a PKC-zeta-specific inhibitor pseudosubstrate peptide was delivered into cells. These data indicate that PKC-zeta plays an important role in HPIV3 gene expression by phosphorylating P protein, thus providing an opportunity to develop antiviral agents against an important human pathogen." @default.
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• W2011120216 date "1995-05-23" @default.
• W2011120216 modified "2023-10-01" @default.
• W2011120216 title "Cellular protein kinase C isoform zeta regulates human parainfluenza virus type 3 replication." @default.
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• W2011120216 doi "https://doi.org/10.1073/pnas.92.11.5204" @default.
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