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- W2011120411 abstract "SummaryDiurnal rhythm of plasma cortisol was determined using a fluaorometric method to measure the levels of 11-hydroxycorticosteroids in venous blood samples collected at 8.00 a.m. and 10.00p.m. in 68 patients with definite rheumatoid arthritis. Thirty-four of these patients were receiving long-term oral corticosteroid therapy. The remaining 34 age and sex-matched patients, who had never previously received corticosteroid drugs, served as controls and helped to provide the normal range of diurnal rhythm of plasma cortisol. Using this normal range, 16 of the 34 corticosteroid-treated rheumatoid patients were found to have abnormal diurnal rhythm. Three of these 16 patients had normal hypothalmo-pituitary-adrenal function as tested by tetracosactrin, lysine 8-vasopressin, insulin hypoglycaemia and metyrapone. Of 18 patients receiving corticosteroid therapy and with normal diurnal rhythm of plasma cortisol, 8 had normal responses to tetracosactrin, lysine8-vasopressin, insulin hypoglycaemia and metyrapone ..." @default.
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- W2011120411 title "Some clinical observations on the diurnal rhythm of plasma cortisol (11-OHCS) in patients with rheumatoid arthritis treated with oral corticosteroid drugs" @default.
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- W2011120411 doi "https://doi.org/10.1185/03007997409112653" @default.
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