FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011121591> ?p ?o ?g. }

• W2011121591 endingPage "1502" @default.
• W2011121591 startingPage "1491" @default.
• W2011121591 abstract "Defining the source of HIV-1 RNA in cerebrospinal fluid (CSF) will facilitate studies of treatment efficacy in the brain. Four antiretroviral drug-naive adults underwent two 48-hr ultraintensive CSF sampling procedures, once at baseline and again beginning on day 4 after initiating three-drug therapy with stavudine, lamivudine, and nelfinavir. At baseline, constant CSF HIV-1 RNA concentrations were maintained by daily entry of at least 104 to 106 HIV-1 RNA copies into CSF. Change from baseline to day 5 ranged from -0.38 to -1.18 log10 HIV-1 RNA copies/ml in CSF, and from -0.80 to -1.33 log10 HIV-1 RNA copies/ml in plasma, with no correlation between CSF and plasma changes. There was no evidence of genotypic or phenotypic viral resistance in either CSF or plasma. With regard to pharmacokinetics, mean CSF-to-plasma area-under-the-curve (AUC) ratios were 38.9% for stavudine and 15.3% for lamivudine. Nelfinavir and its active M8 metabolite could not be accurately quantified in CSF, although plasma M8 peak level and AUC0-8hr correlated with CSF HIV-1 RNA decline. This study supports the utility of ultraintensive CSF sampling for studying HIV-1 pathogenesis and therapy in the CNS, and provides strong evidence that HIV-1 RNA in CSF arises, at least in part, from a source other than plasma." @default.
• W2011121591 created "2016-06-24" @default.
• W2011121591 creator A5000661466 @default.
• W2011121591 creator A5004342709 @default.
• W2011121591 creator A5010011309 @default.
• W2011121591 creator A5010619951 @default.
• W2011121591 creator A5016042608 @default.
• W2011121591 creator A5017051528 @default.
• W2011121591 creator A5018903753 @default.
• W2011121591 creator A5020413975 @default.
• W2011121591 creator A5020915167 @default.
• W2011121591 creator A5022441333 @default.
• W2011121591 creator A5023816846 @default.
• W2011121591 creator A5032129482 @default.
• W2011121591 creator A5047099399 @default.
• W2011121591 creator A5048989224 @default.
• W2011121591 creator A5064604409 @default.
• W2011121591 creator A5071879780 @default.
• W2011121591 creator A5075817852 @default.
• W2011121591 date "2000-10-10" @default.
• W2011121591 modified "2023-10-04" @default.
• W2011121591 title "Evidence of a Source of HIV Type 1 within the Central Nervous System by Ultraintensive Sampling of Cerebrospinal Fluid and Plasma" @default.
• W2011121591 cites W126865375 @default.
• W2011121591 cites W1973398091 @default.
• W2011121591 cites W1974449994 @default.
• W2011121591 cites W1978021511 @default.
• W2011121591 cites W2011630381 @default.
• W2011121591 cites W2020522761 @default.
• W2011121591 cites W2021690008 @default.
• W2011121591 cites W2024442062 @default.
• W2011121591 cites W2026512368 @default.
• W2011121591 cites W2029097526 @default.
• W2011121591 cites W2034359974 @default.
• W2011121591 cites W2047890674 @default.
• W2011121591 cites W2054082662 @default.
• W2011121591 cites W2054973971 @default.
• W2011121591 cites W2055989273 @default.
• W2011121591 cites W2060894064 @default.
• W2011121591 cites W2064039123 @default.
• W2011121591 cites W2064640714 @default.
• W2011121591 cites W2068946470 @default.
• W2011121591 cites W2075171892 @default.
• W2011121591 cites W2081203389 @default.
• W2011121591 cites W2083336840 @default.
• W2011121591 cites W2087426245 @default.
• W2011121591 cites W2091991379 @default.
• W2011121591 cites W2095273553 @default.
• W2011121591 cites W2101062947 @default.
• W2011121591 cites W2114994968 @default.
• W2011121591 cites W2120155625 @default.
• W2011121591 cites W2125202557 @default.
• W2011121591 cites W2134301861 @default.
• W2011121591 cites W2149420389 @default.
• W2011121591 cites W2150357065 @default.
• W2011121591 cites W2156226084 @default.
• W2011121591 cites W2156632979 @default.
• W2011121591 cites W2157390600 @default.
• W2011121591 cites W2170219825 @default.
• W2011121591 cites W2294962982 @default.
• W2011121591 cites W2321751066 @default.
• W2011121591 cites W2323645815 @default.
• W2011121591 cites W2325545802 @default.
• W2011121591 cites W2329393410 @default.
• W2011121591 cites W2330014270 @default.
• W2011121591 cites W2333042560 @default.
• W2011121591 cites W2333397809 @default.
• W2011121591 cites W2339219218 @default.
• W2011121591 cites W270984689 @default.
• W2011121591 cites W3023011256 @default.
• W2011121591 doi "https://doi.org/10.1089/088922200750006010" @default.
• W2011121591 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11054262" @default.
• W2011121591 hasPublicationYear "2000" @default.
• W2011121591 type Work @default.
• W2011121591 sameAs 2011121591 @default.
• W2011121591 citedByCount "43" @default.
• W2011121591 countsByYear W20111215912012 @default.
• W2011121591 countsByYear W20111215912013 @default.
• W2011121591 countsByYear W20111215912014 @default.
• W2011121591 countsByYear W20111215912015 @default.
• W2011121591 countsByYear W20111215912019 @default.
• W2011121591 countsByYear W20111215912023 @default.
• W2011121591 crossrefType "journal-article" @default.
• W2011121591 hasAuthorship W2011121591A5000661466 @default.
• W2011121591 hasAuthorship W2011121591A5004342709 @default.
• W2011121591 hasAuthorship W2011121591A5010011309 @default.
• W2011121591 hasAuthorship W2011121591A5010619951 @default.
• W2011121591 hasAuthorship W2011121591A5016042608 @default.
• W2011121591 hasAuthorship W2011121591A5017051528 @default.
• W2011121591 hasAuthorship W2011121591A5018903753 @default.
• W2011121591 hasAuthorship W2011121591A5020413975 @default.
• W2011121591 hasAuthorship W2011121591A5020915167 @default.
• W2011121591 hasAuthorship W2011121591A5022441333 @default.
• W2011121591 hasAuthorship W2011121591A5023816846 @default.
• W2011121591 hasAuthorship W2011121591A5032129482 @default.
• W2011121591 hasAuthorship W2011121591A5047099399 @default.
• W2011121591 hasAuthorship W2011121591A5048989224 @default.
• W2011121591 hasAuthorship W2011121591A5064604409 @default.
• W2011121591 hasAuthorship W2011121591A5071879780 @default.

• next