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• W2011122692 abstract "This study characterizes cardiovascular autonomic function in women with irritable bowel syndrome (IBS), using standardized techniques.Autonomic dysfunction is believed to contribute to abnormal gastrointestinal motility and visceral hypersensitivity in IBS. There is mounting evidence of generalized impairment of autonomic activity in patients with IBS.Thirty women aged 39 years (95% C.I. 25-53 years) diagnosed with IBS, and 30 age-matched healthy women were studied. The ratio of low frequency to high frequency heart rate variability domains (LF:HF ratio) was used to represent cardiac sympathovagal activity, and orthostatic testing and sustained isometric handgrip exercise were used as sympathetic stimuli. Parasympathetic activity was represented by the expiratory to inspiratory R-R interval (E:I) ratio during deep breathing at 6 minutes.LF:HF responses to handgrip exercise (316%, C.I. 134% to 498% vs. 107%, C.I. 15% to 153%; P < 0.05) and orthostatic testing (648%, C.I. 520% to 904% vs. 330%, C.I. 140% to 520%; P < 0.05) were higher in IBS patients than controls, and the E:I ratio was significantly lower (1.47, C.I. 1.33-1.61 vs. 1.20, C.I. 1.14-1.26; P < 0.01).Autonomic cardiovascular function is impaired in IBS, manifest as attenuated cardio-vagal tone, and relative sympathetic excess during stimulated conditions." @default.
• W2011122692 created "2016-06-24" @default.
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• W2011122692 date "2004-09-01" @default.
• W2011122692 modified "2023-10-16" @default.
• W2011122692 title "Autonomic Cardiovascular Responses Are Impaired in Women With Irritable Bowel Syndrome" @default.
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• W2011122692 doi "https://doi.org/10.1097/01.mcg.0000135362.35665.49" @default.
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