FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011124160> ?p ?o ?g. }

• W2011124160 endingPage "764" @default.
• W2011124160 startingPage "754" @default.
• W2011124160 abstract "The aim of our study was to gain a better understanding of the molecular mechanism underlying the previously unrecognized role of cytoplasmic alpha fetoprotein (AFP) in retinoic acid receptors (RAR) mediated expression and biological effects of GADD153. Using microarray analysis, the expression of the GADD153 gene showed the greatest fold change among apoptosis/growth related genes in response to ATRA. AFP was able to interact with RAR in HepG2 cells, which was undetectable in HLE cells owing to absence of AFP. ATRA promoted nuclei entrance of RAR, expression of GADD153 and apoptosis, and these changes were reversed after transfection with the afp gene or addition of AGN193109. The level of GADD153 was gradually elevated as the effect of AFP was counteracted by increasing dose or prolonging treatment time with ATRA in HepG2 cells. Knockdown of AFP in siRNA-transfected HepG2 cells or over-expression of AFP in afp gene-transfected HLE cells was synchronously associated with up-regulation or down-regulation, respectively, of GADD153 expression. Both ATRA administration and AFP knockdown were each able to promote greater binding of RAR to its response element with consequent elevation of the proportion of apoptotic cells. Conversely, transfection of HLE cells with pcDNA3.1-afp resulted in apparent reduction of RAR binding to DNA and change of biological effect. These data taken together demonstrate the involvement of AFP in RAR-mediated expression and biological effects of GADD153. These findings provide a novel insight into the mechanism underlying the impact of AFP on the RAR signal network." @default.
• W2011124160 created "2016-06-24" @default.
• W2011124160 creator A5006219539 @default.
• W2011124160 creator A5030199923 @default.
• W2011124160 creator A5031172404 @default.
• W2011124160 creator A5032026879 @default.
• W2011124160 creator A5044786927 @default.
• W2011124160 creator A5055299862 @default.
• W2011124160 creator A5056621420 @default.
• W2011124160 creator A5089966579 @default.
• W2011124160 date "2011-11-09" @default.
• W2011124160 modified "2023-10-03" @default.
• W2011124160 title "Impact of intracellular alpha fetoprotein on retinoic acid receptors-mediated expression of GADD153 in human hepatoma cell lines" @default.
• W2011124160 cites W1969248336 @default.
• W2011124160 cites W1973119390 @default.
• W2011124160 cites W1975547847 @default.
• W2011124160 cites W1990989209 @default.
• W2011124160 cites W1993319491 @default.
• W2011124160 cites W1995180061 @default.
• W2011124160 cites W1999923261 @default.
• W2011124160 cites W2003875283 @default.
• W2011124160 cites W2015444534 @default.
• W2011124160 cites W2017444268 @default.
• W2011124160 cites W2019247074 @default.
• W2011124160 cites W2019424220 @default.
• W2011124160 cites W2025511820 @default.
• W2011124160 cites W2038921011 @default.
• W2011124160 cites W2040347441 @default.
• W2011124160 cites W2054419318 @default.
• W2011124160 cites W2060219833 @default.
• W2011124160 cites W2094576171 @default.
• W2011124160 cites W2110349817 @default.
• W2011124160 cites W2113286169 @default.
• W2011124160 cites W2115386094 @default.
• W2011124160 cites W2123125812 @default.
• W2011124160 cites W2124418353 @default.
• W2011124160 cites W2126149370 @default.
• W2011124160 cites W2134456945 @default.
• W2011124160 cites W2148623636 @default.
• W2011124160 cites W2155152791 @default.
• W2011124160 cites W2164457641 @default.
• W2011124160 cites W2168415166 @default.
• W2011124160 cites W2948416922 @default.
• W2011124160 doi "https://doi.org/10.1002/ijc.26025" @default.
• W2011124160 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21365646" @default.
• W2011124160 hasPublicationYear "2011" @default.
• W2011124160 type Work @default.
• W2011124160 sameAs 2011124160 @default.
• W2011124160 citedByCount "27" @default.
• W2011124160 countsByYear W20111241602012 @default.
• W2011124160 countsByYear W20111241602013 @default.
• W2011124160 countsByYear W20111241602015 @default.
• W2011124160 countsByYear W20111241602016 @default.
• W2011124160 countsByYear W20111241602017 @default.
• W2011124160 countsByYear W20111241602018 @default.
• W2011124160 countsByYear W20111241602020 @default.
• W2011124160 countsByYear W20111241602021 @default.
• W2011124160 countsByYear W20111241602023 @default.
• W2011124160 crossrefType "journal-article" @default.
• W2011124160 hasAuthorship W2011124160A5006219539 @default.
• W2011124160 hasAuthorship W2011124160A5030199923 @default.
• W2011124160 hasAuthorship W2011124160A5031172404 @default.
• W2011124160 hasAuthorship W2011124160A5032026879 @default.
• W2011124160 hasAuthorship W2011124160A5044786927 @default.
• W2011124160 hasAuthorship W2011124160A5055299862 @default.
• W2011124160 hasAuthorship W2011124160A5056621420 @default.
• W2011124160 hasAuthorship W2011124160A5089966579 @default.
• W2011124160 hasConcept C104317684 @default.
• W2011124160 hasConcept C120197328 @default.
• W2011124160 hasConcept C150194340 @default.
• W2011124160 hasConcept C153911025 @default.
• W2011124160 hasConcept C159110408 @default.
• W2011124160 hasConcept C170493617 @default.
• W2011124160 hasConcept C173396325 @default.
• W2011124160 hasConcept C190283241 @default.
• W2011124160 hasConcept C2775944032 @default.
• W2011124160 hasConcept C2778019345 @default.
• W2011124160 hasConcept C2780624289 @default.
• W2011124160 hasConcept C2781121885 @default.
• W2011124160 hasConcept C49453240 @default.
• W2011124160 hasConcept C502942594 @default.
• W2011124160 hasConcept C54009773 @default.
• W2011124160 hasConcept C55493867 @default.
• W2011124160 hasConcept C64943373 @default.
• W2011124160 hasConcept C71924100 @default.
• W2011124160 hasConcept C86803240 @default.
• W2011124160 hasConcept C95444343 @default.
• W2011124160 hasConceptScore W2011124160C104317684 @default.
• W2011124160 hasConceptScore W2011124160C120197328 @default.
• W2011124160 hasConceptScore W2011124160C150194340 @default.
• W2011124160 hasConceptScore W2011124160C153911025 @default.
• W2011124160 hasConceptScore W2011124160C159110408 @default.
• W2011124160 hasConceptScore W2011124160C170493617 @default.
• W2011124160 hasConceptScore W2011124160C173396325 @default.
• W2011124160 hasConceptScore W2011124160C190283241 @default.
• W2011124160 hasConceptScore W2011124160C2775944032 @default.
• W2011124160 hasConceptScore W2011124160C2778019345 @default.
• W2011124160 hasConceptScore W2011124160C2780624289 @default.

• next