Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011125061> ?p ?o ?g. }
- W2011125061 endingPage "146" @default.
- W2011125061 startingPage "133" @default.
- W2011125061 abstract "Pluronic® F127 grafted poly (methyl vinyl ether-alt-maleic acid) copolymer was synthesized using dicyclohexylcarbodiimide and dimethylaminopyridine to prepare a suitable micellar carrier for delivery of doxorubicin (DOX) in breast cancer. The copolymer structure was confirmed by 1H NMR and FTIR. Critical micelle concentration (CMC) of the copolymer was determined by pyrene as a fluorescent probe. DOX was loaded in micelles by direct dissolution method, and the physical properties of micelles; including particle size, zeta potential, drug loading efficiency and drug release profiles were studied. The cytotoxicity of micelles loaded with DOX in different concentrations was studied in MCF-7 cells using MTT assay. FTIR and 1H NMR spectra confirmed successful production of the copolymeric micelles with CMC of 390 μg/ml. Optimized micelles were obtained using 6 mg of DOX per 24 mg of copolymer, a temperature of 45.7 °C, stirring time of 1 h and stirring rate of 400 RPM. This produced micelles with a particle size of 419.1 ± 38.2 nm, zeta potential of −13.3 ± 1.2 mV, an acceptable drug loading efficiency of 93.5 ± 2.7% and the release efficiency of 29.0 ± 3.1%. The release test at 4 h showed a sustained release property. The drug release from copolymer was pH dependent and was faster in pH 5.5 compared to 7.4. The synthesized copolymer was not cytotoxic. Its micelles, when loaded with 0.21 μM of DOX could kill about 48.9 ± 1.7% of MCF-7 cells compared to free DOX; which killed 36.4 ± 1.1% of these cells at the same concentration. This significant difference in cytotoxicity (p < 0.05) seems promising in reducing drug resistance in breast cancer." @default.
- W2011125061 created "2016-06-24" @default.
- W2011125061 creator A5004478122 @default.
- W2011125061 creator A5043690841 @default.
- W2011125061 creator A5065572210 @default.
- W2011125061 creator A5069359520 @default.
- W2011125061 creator A5073494212 @default.
- W2011125061 date "2014-03-01" @default.
- W2011125061 modified "2023-09-26" @default.
- W2011125061 title "Synthesis of Pluronic® F127-poly (methyl vinyl ether-alt-maleic acid) copolymer and production of its micelles for doxorubicin delivery in breast cancer" @default.
- W2011125061 cites W1966345384 @default.
- W2011125061 cites W1970447790 @default.
- W2011125061 cites W1970655806 @default.
- W2011125061 cites W1972670975 @default.
- W2011125061 cites W1973418234 @default.
- W2011125061 cites W1974940854 @default.
- W2011125061 cites W1976371089 @default.
- W2011125061 cites W1978210381 @default.
- W2011125061 cites W1978466251 @default.
- W2011125061 cites W1979530522 @default.
- W2011125061 cites W1980207776 @default.
- W2011125061 cites W1981696575 @default.
- W2011125061 cites W1982938211 @default.
- W2011125061 cites W1985134617 @default.
- W2011125061 cites W1987424920 @default.
- W2011125061 cites W1993285875 @default.
- W2011125061 cites W1993895985 @default.
- W2011125061 cites W1994627996 @default.
- W2011125061 cites W1995995697 @default.
- W2011125061 cites W1996169268 @default.
- W2011125061 cites W2002975193 @default.
- W2011125061 cites W2007124962 @default.
- W2011125061 cites W2010197849 @default.
- W2011125061 cites W2012756671 @default.
- W2011125061 cites W2015346163 @default.
- W2011125061 cites W2018469932 @default.
- W2011125061 cites W2025653403 @default.
- W2011125061 cites W2025722135 @default.
- W2011125061 cites W2027415692 @default.
- W2011125061 cites W2029351008 @default.
- W2011125061 cites W2030579793 @default.
- W2011125061 cites W2034383957 @default.
- W2011125061 cites W2036459378 @default.
- W2011125061 cites W2037366020 @default.
- W2011125061 cites W2037732086 @default.
- W2011125061 cites W2038011320 @default.
- W2011125061 cites W2042447917 @default.
- W2011125061 cites W2043445121 @default.
- W2011125061 cites W2046387264 @default.
- W2011125061 cites W2050165248 @default.
- W2011125061 cites W2050296608 @default.
- W2011125061 cites W2051140239 @default.
- W2011125061 cites W2062874552 @default.
- W2011125061 cites W2063193456 @default.
- W2011125061 cites W2064706547 @default.
- W2011125061 cites W2067476902 @default.
- W2011125061 cites W2071240608 @default.
- W2011125061 cites W2071755681 @default.
- W2011125061 cites W2072289689 @default.
- W2011125061 cites W2072952062 @default.
- W2011125061 cites W2089055004 @default.
- W2011125061 cites W2092666165 @default.
- W2011125061 cites W2108974866 @default.
- W2011125061 cites W2123927174 @default.
- W2011125061 cites W2127667644 @default.
- W2011125061 cites W2143239775 @default.
- W2011125061 cites W2156957394 @default.
- W2011125061 cites W2171384411 @default.
- W2011125061 doi "https://doi.org/10.1016/j.cej.2013.11.086" @default.
- W2011125061 hasPublicationYear "2014" @default.
- W2011125061 type Work @default.
- W2011125061 sameAs 2011125061 @default.
- W2011125061 citedByCount "33" @default.
- W2011125061 countsByYear W20111250612014 @default.
- W2011125061 countsByYear W20111250612015 @default.
- W2011125061 countsByYear W20111250612016 @default.
- W2011125061 countsByYear W20111250612017 @default.
- W2011125061 countsByYear W20111250612018 @default.
- W2011125061 countsByYear W20111250612019 @default.
- W2011125061 countsByYear W20111250612020 @default.
- W2011125061 countsByYear W20111250612021 @default.
- W2011125061 countsByYear W20111250612022 @default.
- W2011125061 countsByYear W20111250612023 @default.
- W2011125061 crossrefType "journal-article" @default.
- W2011125061 hasAuthorship W2011125061A5004478122 @default.
- W2011125061 hasAuthorship W2011125061A5043690841 @default.
- W2011125061 hasAuthorship W2011125061A5065572210 @default.
- W2011125061 hasAuthorship W2011125061A5069359520 @default.
- W2011125061 hasAuthorship W2011125061A5073494212 @default.
- W2011125061 hasConcept C101335993 @default.
- W2011125061 hasConcept C11268172 @default.
- W2011125061 hasConcept C127413603 @default.
- W2011125061 hasConcept C13245373 @default.
- W2011125061 hasConcept C13965031 @default.
- W2011125061 hasConcept C147789679 @default.
- W2011125061 hasConcept C155672457 @default.
- W2011125061 hasConcept C15920480 @default.
- W2011125061 hasConcept C160892712 @default.