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• W2011125600 abstract "Nicotinamide phosphoribosyltransferase (NAMPT) was first reported as a pre-B-cell colony enhancing factor in 1994 with little notice, but it has received increasing attention in recent years due to accumulating evidence indicating that NAMPT is a pleiotropic protein such as a growth factor, a cytokine, an enzyme and a visfatin. Now, NAMPT has been accepted as an official name of this protein. Because of NAMPT's multiple functions in a variety of physiological processes, their dysregulations have been implicated in the pathogenesis of a number of human diseases or conditions such as acute lung injury, aging, atherosclerosis, cancer, diabetes, rheumatoid arthritis and sepsis. This review will cover the current understanding of NAMPT's structure and functions with an emphasis on recent progress of nicotinamide phosphoribosyltransferase's pathological roles in various human diseases and conditions. Future directions on exploring its Terra incognita will be offered in the end." @default.
• W2011125600 created "2016-06-24" @default.
• W2011125600 creator A5008549495 @default.
• W2011125600 creator A5057916843 @default.
• W2011125600 creator A5062021652 @default.
• W2011125600 date "2011-01-01" @default.
• W2011125600 modified "2023-09-27" @default.
• W2011125600 title "Nicotinamide Phosphoribosyltransferase in Human Diseases" @default.
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