FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011126025> ?p ?o ?g. }

• W2011126025 endingPage "17" @default.
• W2011126025 startingPage "10" @default.
• W2011126025 abstract "Previous studies have demonstrated that N,N-diethyldithiocarbamate (DEDC) elevates copper and promotes oxidative stress within the nervous system. However, whether these effects resolve following cessation of exposure or have the potential to persist and result in cumulative injury has not been determined. In this study, an established model for DEDC myelin injury in the rat was used to determine whether copper levels, oxidative stress, and neuromuscular deficits resolve following the cessation of DEDC exposure. Rats were exposed to DEDC for 8 weeks and then either euthanized or maintained for 2, 6 or 12 weeks after cessation of exposure. At each time point copper levels were measured by inductively coupled mass spectrometry to assess the ability of sciatic nerve, brain, spinal cord and liver to eliminate excess copper post-exposure. The protein expression levels of glutathione transferase alpha, heme oxygenase 1 and superoxide dismutase 1 in peripheral nerve and brain were also determined by western blot to assess levels of oxidative stress as a function of post-exposure duration. As an initial assessment of the bioavailability of the excess copper in brain the protein expression levels of copper chaperone for superoxide dismutase 1, and prion protein were determined by western blot as a function of exposure and post-exposure duration. Neuromuscular function in peripheral nerve was evaluated using grip strengths, nerve conduction velocities, and morphologic changes at the light microscope level. The data demonstrated that in peripheral nerve, copper levels and oxidative stress return to control levels within several weeks after cessation of exposure. Neuromuscular function also showed a trend towards pre-exposure values, although the resolution of myelin lesions was more delayed. In contrast, total copper and antioxidant enzyme levels remained significantly elevated in brain for longer post-exposure periods. The persistence of effects observed in brain suggests that the central nervous system is more susceptible to long-term cumulative adverse effects from dithiocarbamates. Additionally, significant changes in expression levels of chaperone for superoxide dismutase 1, and prion protein were observed consistent with at least a portion of the excess copper being bioactive." @default.
• W2011126025 created "2016-06-24" @default.
• W2011126025 creator A5025690886 @default.
• W2011126025 creator A5031078702 @default.
• W2011126025 creator A5044621021 @default.
• W2011126025 date "2010-07-01" @default.
• W2011126025 modified "2023-09-23" @default.
• W2011126025 title "Peripheral nerve and brain differ in their capacity to resolve N,N-diethyldithiocarbamate-mediated elevations in copper and oxidative injury" @default.
• W2011126025 cites W1535773271 @default.
• W2011126025 cites W1850459552 @default.
• W2011126025 cites W1900200896 @default.
• W2011126025 cites W1970255281 @default.
• W2011126025 cites W2004051173 @default.
• W2011126025 cites W2004143867 @default.
• W2011126025 cites W2007134400 @default.
• W2011126025 cites W2009160884 @default.
• W2011126025 cites W2019365387 @default.
• W2011126025 cites W2036170464 @default.
• W2011126025 cites W2040964500 @default.
• W2011126025 cites W2045705413 @default.
• W2011126025 cites W2070895420 @default.
• W2011126025 cites W2083755443 @default.
• W2011126025 cites W2094748584 @default.
• W2011126025 cites W2099018685 @default.
• W2011126025 cites W2118865702 @default.
• W2011126025 cites W2119503340 @default.
• W2011126025 cites W2120635360 @default.
• W2011126025 cites W2146883699 @default.
• W2011126025 cites W2148110404 @default.
• W2011126025 cites W2158188211 @default.
• W2011126025 cites W2162209124 @default.
• W2011126025 cites W2165615907 @default.
• W2011126025 cites W2302267746 @default.
• W2011126025 cites W4243048085 @default.
• W2011126025 doi "https://doi.org/10.1016/j.tox.2010.04.018" @default.
• W2011126025 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2900428" @default.
• W2011126025 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20452388" @default.
• W2011126025 hasPublicationYear "2010" @default.
• W2011126025 type Work @default.
• W2011126025 sameAs 2011126025 @default.
• W2011126025 citedByCount "5" @default.
• W2011126025 countsByYear W20111260252013 @default.
• W2011126025 countsByYear W20111260252015 @default.
• W2011126025 countsByYear W20111260252017 @default.
• W2011126025 countsByYear W20111260252023 @default.
• W2011126025 crossrefType "journal-article" @default.
• W2011126025 hasAuthorship W2011126025A5025690886 @default.
• W2011126025 hasAuthorship W2011126025A5031078702 @default.
• W2011126025 hasAuthorship W2011126025A5044621021 @default.
• W2011126025 hasBestOaLocation W20111260252 @default.
• W2011126025 hasConcept C105702510 @default.
• W2011126025 hasConcept C126322002 @default.
• W2011126025 hasConcept C169760540 @default.
• W2011126025 hasConcept C178790620 @default.
• W2011126025 hasConcept C185592680 @default.
• W2011126025 hasConcept C2776151105 @default.
• W2011126025 hasConcept C3018498973 @default.
• W2011126025 hasConcept C3020296196 @default.
• W2011126025 hasConcept C46762472 @default.
• W2011126025 hasConcept C544778455 @default.
• W2011126025 hasConcept C55493867 @default.
• W2011126025 hasConcept C57600042 @default.
• W2011126025 hasConcept C71924100 @default.
• W2011126025 hasConcept C86803240 @default.
• W2011126025 hasConceptScore W2011126025C105702510 @default.
• W2011126025 hasConceptScore W2011126025C126322002 @default.
• W2011126025 hasConceptScore W2011126025C169760540 @default.
• W2011126025 hasConceptScore W2011126025C178790620 @default.
• W2011126025 hasConceptScore W2011126025C185592680 @default.
• W2011126025 hasConceptScore W2011126025C2776151105 @default.
• W2011126025 hasConceptScore W2011126025C3018498973 @default.
• W2011126025 hasConceptScore W2011126025C3020296196 @default.
• W2011126025 hasConceptScore W2011126025C46762472 @default.
• W2011126025 hasConceptScore W2011126025C544778455 @default.
• W2011126025 hasConceptScore W2011126025C55493867 @default.
• W2011126025 hasConceptScore W2011126025C57600042 @default.
• W2011126025 hasConceptScore W2011126025C71924100 @default.
• W2011126025 hasConceptScore W2011126025C86803240 @default.
• W2011126025 hasIssue "1-3" @default.
• W2011126025 hasLocation W20111260251 @default.
• W2011126025 hasLocation W20111260252 @default.
• W2011126025 hasLocation W20111260253 @default.
• W2011126025 hasOpenAccess W2011126025 @default.
• W2011126025 hasPrimaryLocation W20111260251 @default.
• W2011126025 hasRelatedWork W1991408025 @default.
• W2011126025 hasRelatedWork W2009479492 @default.
• W2011126025 hasRelatedWork W2035609552 @default.
• W2011126025 hasRelatedWork W2132160802 @default.
• W2011126025 hasRelatedWork W2594766789 @default.
• W2011126025 hasRelatedWork W2908340616 @default.
• W2011126025 hasRelatedWork W2995565002 @default.
• W2011126025 hasRelatedWork W3084245137 @default.
• W2011126025 hasRelatedWork W4281660987 @default.
• W2011126025 hasRelatedWork W4287010262 @default.
• W2011126025 hasVolume "274" @default.
• W2011126025 isParatext "false" @default.
• W2011126025 isRetracted "false" @default.
• W2011126025 magId "2011126025" @default.

• next