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• W2011128411 abstract "Abstract Multiple-dose units have many kinetic and therapeutic advantages over single-dose sustained-release units. We therefore investigated the influence of pellet core properties and different coating parameters on in vitro theophylline release. Pellet size and pellet surface have a distinct effect on the release behaviour, with the surface morphology also playing a major role. One organic solvent-based and two aqueous dispersion-based polymer systems for sustained-release diffusion membranes were compared with respect to the influence of coating process parameters. The product bed temperature, an important process parameter, proved to be noncritical for the organic solvent-based system within a product bed temperature range of 30–45 °C, as was demonstrated by well reproducible release values. Since the release values showed a distinctly higher relative standard deviation at the lower spray rate, probably due to spray losses, the spray rate has to be carefully optimised. With one of the aqueous sustained-release systems, both the product bed temperature and the subsequent curing phase which was carried out at a fixed relative humidity and which needed to be sufficiently long had a decisive effect on the release rate. Modern fluid-bed techniques render anti-adhesives, such as talc, largely superfluous for the aforementioned sustained-release systems. When opting for organic solvent-based sustained-release systems, the technicalities of solvent recovery must be taken into consideration due to legal requirements concerning their emission. Compared with organic solvent-based lacquer systems, aqueous latex systems involve higher development and production costs, as has been demonstrated by the influence of the product bed temperature and the subsequent curing." @default.
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• W2011128411 date "1997-04-01" @default.
• W2011128411 modified "2023-09-27" @default.
• W2011128411 title "Influence of process parameters on sustained-release theophylline pellets coated with aqueous polymer dispersions and organic solvent-based polymer solutions" @default.
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• W2011128411 doi "https://doi.org/10.1016/s0939-6411(96)00035-5" @default.
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