Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011128970> ?p ?o ?g. }
- W2011128970 endingPage "63" @default.
- W2011128970 startingPage "57" @default.
- W2011128970 abstract "Clinical and experimental studies pertinent for demonstrating the antipsychotic potential of benzodiazepines (BDZ) and the involvement of γ-aminobutyric acid (GABA) in the origin of schizophrenia are reviewed. It is shown that, due to severe methodological problems and pitfalls, placebo-controlled, double-blind studies do not permit unequivocal conclusions on the efficacy of BDZs, but neither do they completely disprove it. Furthermore, at first glance, confusing and controversial findings in animal models indicate a bi-directionality of effects of full BDZ agonists on dopamine-mediated functions, which may perhaps be explained by (i) anatomical and functional organization of the GABA-dopamine system in the nigro-striatal and ventro tegmental area, and (ii) the regional non-selectivity of action of these drugs. The recent demonstration of structural polymorphism of the GABA A -BDZ receptor complex and heterogeneous distribution of sets of subunits of the GABA A -BDZ receptor in the brain, suggests possibilities for development of partial BDZ agonists showing greater regional selectivity of action and thus potentially more specific antipsychotic action. Initial clinical results with bretazenil (Ro 16-6028), a partial BDZ agonist, in acute schizophrenia are, in this respect, an encouraging lead to be followed further." @default.
- W2011128970 created "2016-06-24" @default.
- W2011128970 creator A5055911575 @default.
- W2011128970 creator A5073770374 @default.
- W2011128970 date "1995-01-01" @default.
- W2011128970 modified "2023-09-24" @default.
- W2011128970 title "Benzodiazepines and GABA hypothesis of schizophrenia" @default.
- W2011128970 cites W190233593 @default.
- W2011128970 cites W1967132451 @default.
- W2011128970 cites W1988790725 @default.
- W2011128970 cites W1992469328 @default.
- W2011128970 cites W1993408357 @default.
- W2011128970 cites W1994383216 @default.
- W2011128970 cites W1996339077 @default.
- W2011128970 cites W2008621323 @default.
- W2011128970 cites W2013347737 @default.
- W2011128970 cites W2015077338 @default.
- W2011128970 cites W2017496314 @default.
- W2011128970 cites W2017881870 @default.
- W2011128970 cites W2020245639 @default.
- W2011128970 cites W2020319462 @default.
- W2011128970 cites W2021231778 @default.
- W2011128970 cites W2023469110 @default.
- W2011128970 cites W2025152691 @default.
- W2011128970 cites W2028864767 @default.
- W2011128970 cites W2029148657 @default.
- W2011128970 cites W2034391820 @default.
- W2011128970 cites W2042919784 @default.
- W2011128970 cites W2052273656 @default.
- W2011128970 cites W2052591190 @default.
- W2011128970 cites W2054940437 @default.
- W2011128970 cites W2066883358 @default.
- W2011128970 cites W2067884699 @default.
- W2011128970 cites W2072031818 @default.
- W2011128970 cites W2078065500 @default.
- W2011128970 cites W2084906880 @default.
- W2011128970 cites W2086415099 @default.
- W2011128970 cites W2090937361 @default.
- W2011128970 cites W2127776863 @default.
- W2011128970 cites W2158648681 @default.
- W2011128970 cites W2164717837 @default.
- W2011128970 cites W2330520786 @default.
- W2011128970 cites W2405692750 @default.
- W2011128970 cites W2412320762 @default.
- W2011128970 cites W2417944685 @default.
- W2011128970 cites W2492595456 @default.
- W2011128970 cites W64322893 @default.
- W2011128970 doi "https://doi.org/10.1177/026988119500900109" @default.
- W2011128970 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22298694" @default.
- W2011128970 hasPublicationYear "1995" @default.
- W2011128970 type Work @default.
- W2011128970 sameAs 2011128970 @default.
- W2011128970 citedByCount "15" @default.
- W2011128970 countsByYear W20111289702013 @default.
- W2011128970 countsByYear W20111289702021 @default.
- W2011128970 crossrefType "journal-article" @default.
- W2011128970 hasAuthorship W2011128970A5055911575 @default.
- W2011128970 hasAuthorship W2011128970A5073770374 @default.
- W2011128970 hasConcept C118552586 @default.
- W2011128970 hasConcept C120069818 @default.
- W2011128970 hasConcept C126322002 @default.
- W2011128970 hasConcept C15744967 @default.
- W2011128970 hasConcept C169760540 @default.
- W2011128970 hasConcept C170457331 @default.
- W2011128970 hasConcept C170493617 @default.
- W2011128970 hasConcept C2776412080 @default.
- W2011128970 hasConcept C2778938600 @default.
- W2011128970 hasConcept C2779727114 @default.
- W2011128970 hasConcept C2780494398 @default.
- W2011128970 hasConcept C38533456 @default.
- W2011128970 hasConcept C513476851 @default.
- W2011128970 hasConcept C58732023 @default.
- W2011128970 hasConcept C71924100 @default.
- W2011128970 hasConcept C98274493 @default.
- W2011128970 hasConceptScore W2011128970C118552586 @default.
- W2011128970 hasConceptScore W2011128970C120069818 @default.
- W2011128970 hasConceptScore W2011128970C126322002 @default.
- W2011128970 hasConceptScore W2011128970C15744967 @default.
- W2011128970 hasConceptScore W2011128970C169760540 @default.
- W2011128970 hasConceptScore W2011128970C170457331 @default.
- W2011128970 hasConceptScore W2011128970C170493617 @default.
- W2011128970 hasConceptScore W2011128970C2776412080 @default.
- W2011128970 hasConceptScore W2011128970C2778938600 @default.
- W2011128970 hasConceptScore W2011128970C2779727114 @default.
- W2011128970 hasConceptScore W2011128970C2780494398 @default.
- W2011128970 hasConceptScore W2011128970C38533456 @default.
- W2011128970 hasConceptScore W2011128970C513476851 @default.
- W2011128970 hasConceptScore W2011128970C58732023 @default.
- W2011128970 hasConceptScore W2011128970C71924100 @default.
- W2011128970 hasConceptScore W2011128970C98274493 @default.
- W2011128970 hasIssue "1" @default.
- W2011128970 hasLocation W20111289701 @default.
- W2011128970 hasLocation W20111289702 @default.
- W2011128970 hasOpenAccess W2011128970 @default.
- W2011128970 hasPrimaryLocation W20111289701 @default.
- W2011128970 hasRelatedWork W2014290090 @default.
- W2011128970 hasRelatedWork W2086695839 @default.
- W2011128970 hasRelatedWork W2092580574 @default.