Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011129574> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2011129574 endingPage "7" @default.
- W2011129574 startingPage "1" @default.
- W2011129574 abstract "The mechanism by which ischemia stimulates angiogenesis is unknown. Adenosine is released during myocardial ischemia and may be a mediator of this process. Experimental data suggest that heparin may enhance this effect. The purpose of this open-labeled, placebo-controlled trial was to determine whether repeated intravenous administration of adenosine and heparin could mimic physiologic angiogenesis and reduce the amount of exercise-induced myocardial ischemia in patients with coronary artery disease. Subjects with chronic stable angina refractory to conventional medical therapy and not suitable for revascularization received either adenosine (140 microg/kg/min for 6 minutes) and heparin (10,000 U bolus), (n = 14), or placebo, (n = 7) daily for 10 days. All patients underwent baseline and follow-up exercise testing with thallium-201 single-photon emission computed tomography myocardial perfusion imaging. A semiquantitative assessment of the extent and severity of the perfusion abnormalities was calculated by 2 blinded investigators. There was no significant change in exercise duration or in the peak heart rate systolic blood pressure product associated with adenosine and heparin compared with placebo treatment. There was, however, a 9% reduction in the extent (60.6 +/- 4.0 vs 54.9 +/- 4.1, p = 0.03) and a 14% improvement in severity (41.5 +/- 3.2 vs 35.7 +/- 2.9, p = 0.01) of the myocardial perfusion abnormalities seen in patients who received adenosine and heparin compared with placebo. Thus, in this pilot study, repeated administration of adenosine and heparin reduced the amount of exercise-induced ischemia in patients with chronic stable angina refractory to conventional treatment." @default.
- W2011129574 created "2016-06-24" @default.
- W2011129574 creator A5022749680 @default.
- W2011129574 creator A5028220476 @default.
- W2011129574 creator A5040358030 @default.
- W2011129574 creator A5045935176 @default.
- W2011129574 creator A5078138192 @default.
- W2011129574 date "2000-01-01" @default.
- W2011129574 modified "2023-09-27" @default.
- W2011129574 title "Effects of the repeated administration of adenosine and heparin on myocardial perfusion in patients with chronic stable angina pectoris" @default.
- W2011129574 cites W1524710085 @default.
- W2011129574 cites W1579364872 @default.
- W2011129574 cites W1980408417 @default.
- W2011129574 cites W1983407850 @default.
- W2011129574 cites W2018153873 @default.
- W2011129574 cites W2028793163 @default.
- W2011129574 cites W2031082370 @default.
- W2011129574 cites W2036854260 @default.
- W2011129574 cites W2038782636 @default.
- W2011129574 cites W2043970571 @default.
- W2011129574 cites W2068446076 @default.
- W2011129574 cites W2081013776 @default.
- W2011129574 cites W2118186213 @default.
- W2011129574 cites W2142401146 @default.
- W2011129574 cites W2162249561 @default.
- W2011129574 cites W2346048525 @default.
- W2011129574 cites W2411173551 @default.
- W2011129574 doi "https://doi.org/10.1016/s0002-9149(99)00596-2" @default.
- W2011129574 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11078227" @default.
- W2011129574 hasPublicationYear "2000" @default.
- W2011129574 type Work @default.
- W2011129574 sameAs 2011129574 @default.
- W2011129574 citedByCount "13" @default.
- W2011129574 countsByYear W20111295742019 @default.
- W2011129574 countsByYear W20111295742020 @default.
- W2011129574 crossrefType "journal-article" @default.
- W2011129574 hasAuthorship W2011129574A5022749680 @default.
- W2011129574 hasAuthorship W2011129574A5028220476 @default.
- W2011129574 hasAuthorship W2011129574A5040358030 @default.
- W2011129574 hasAuthorship W2011129574A5045935176 @default.
- W2011129574 hasAuthorship W2011129574A5078138192 @default.
- W2011129574 hasConcept C126322002 @default.
- W2011129574 hasConcept C142724271 @default.
- W2011129574 hasConcept C146957229 @default.
- W2011129574 hasConcept C164705383 @default.
- W2011129574 hasConcept C204787440 @default.
- W2011129574 hasConcept C27081682 @default.
- W2011129574 hasConcept C2776991684 @default.
- W2011129574 hasConcept C2777557582 @default.
- W2011129574 hasConcept C2778213512 @default.
- W2011129574 hasConcept C2778405248 @default.
- W2011129574 hasConcept C2778425758 @default.
- W2011129574 hasConcept C42219234 @default.
- W2011129574 hasConcept C500558357 @default.
- W2011129574 hasConcept C541997718 @default.
- W2011129574 hasConcept C71924100 @default.
- W2011129574 hasConceptScore W2011129574C126322002 @default.
- W2011129574 hasConceptScore W2011129574C142724271 @default.
- W2011129574 hasConceptScore W2011129574C146957229 @default.
- W2011129574 hasConceptScore W2011129574C164705383 @default.
- W2011129574 hasConceptScore W2011129574C204787440 @default.
- W2011129574 hasConceptScore W2011129574C27081682 @default.
- W2011129574 hasConceptScore W2011129574C2776991684 @default.
- W2011129574 hasConceptScore W2011129574C2777557582 @default.
- W2011129574 hasConceptScore W2011129574C2778213512 @default.
- W2011129574 hasConceptScore W2011129574C2778405248 @default.
- W2011129574 hasConceptScore W2011129574C2778425758 @default.
- W2011129574 hasConceptScore W2011129574C42219234 @default.
- W2011129574 hasConceptScore W2011129574C500558357 @default.
- W2011129574 hasConceptScore W2011129574C541997718 @default.
- W2011129574 hasConceptScore W2011129574C71924100 @default.
- W2011129574 hasIssue "1" @default.
- W2011129574 hasLocation W20111295741 @default.
- W2011129574 hasLocation W20111295742 @default.
- W2011129574 hasOpenAccess W2011129574 @default.
- W2011129574 hasPrimaryLocation W20111295741 @default.
- W2011129574 hasRelatedWork W2347475567 @default.
- W2011129574 hasRelatedWork W2350724833 @default.
- W2011129574 hasRelatedWork W2350855849 @default.
- W2011129574 hasRelatedWork W2355493628 @default.
- W2011129574 hasRelatedWork W2355538529 @default.
- W2011129574 hasRelatedWork W2367482111 @default.
- W2011129574 hasRelatedWork W2368253770 @default.
- W2011129574 hasRelatedWork W2370490441 @default.
- W2011129574 hasRelatedWork W2376888114 @default.
- W2011129574 hasRelatedWork W47567210 @default.
- W2011129574 hasVolume "85" @default.
- W2011129574 isParatext "false" @default.
- W2011129574 isRetracted "false" @default.
- W2011129574 magId "2011129574" @default.
- W2011129574 workType "article" @default.