Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011129904> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2011129904 endingPage "10" @default.
- W2011129904 startingPage "1" @default.
- W2011129904 abstract "Vasostatin, a fragment of calreticulin, was transfected in the BON cell line to evaluate the feasibility of using it for gene therapy in neuroendocrine tumors. Vasostatin transfected cells were subcutaneously inoculated in nude mice. Burkitt lymphoma cell line, CA46, colorectal adenocarcinoma cell line, SW480, as well as endothelial cells PAE and SVEC4 were used for evaluating the function of vasostatin. The results demonstrated that vasostatin transfer caused enhanced malignant behavior of neuroendocrine tumor cell line, BON. Cell adhesion, spreading and cellular invasion were also enhanced in vasostatin-expressing BON cells. Tumor suppressor genes including p53, nm23, Rb and vinculin were down-regulated. Moreover, cell cycle regulatory protein, p27kip1, and cell differentiation-related protein kinase, PKR, were also significantly down-regulated. Furthermore, expression of NKG2D ligands, MICA and MICB, were down-regulated. Mice implanted with vasostatin-expressing BON cells showed an earlier and faster tumor growth compared to wild type. Anti-proliferative effects of vasostatin could not be proven in other cells except in PAE. These results indicated that vasostatin does probably not have a tumor growth inhibitory effect by itself, but rather modulates processes which are necessary for tumor growth. Therefore, one should be very careful when using vasostatin as an anti-tumoral agent in clinical trials, at least for neuroendocrine tumors." @default.
- W2011129904 created "2016-06-24" @default.
- W2011129904 creator A5005771821 @default.
- W2011129904 creator A5017410860 @default.
- W2011129904 creator A5025025019 @default.
- W2011129904 creator A5040645190 @default.
- W2011129904 date "2005-01-01" @default.
- W2011129904 modified "2023-09-23" @default.
- W2011129904 title "Gene Transfer of Vasostatin, a Calreticulin Fragment, into Neuroendocrine Tumor Cells Results in Enhanced Malignant Behavior" @default.
- W2011129904 cites W132680443 @default.
- W2011129904 cites W1553825088 @default.
- W2011129904 cites W1573363574 @default.
- W2011129904 cites W1588348996 @default.
- W2011129904 cites W1968186641 @default.
- W2011129904 cites W1974063618 @default.
- W2011129904 cites W1978310574 @default.
- W2011129904 cites W1980365540 @default.
- W2011129904 cites W1985804036 @default.
- W2011129904 cites W1990122501 @default.
- W2011129904 cites W1990888903 @default.
- W2011129904 cites W1997356690 @default.
- W2011129904 cites W1999191024 @default.
- W2011129904 cites W2004479219 @default.
- W2011129904 cites W2004768524 @default.
- W2011129904 cites W2018293082 @default.
- W2011129904 cites W2020006960 @default.
- W2011129904 cites W2030679896 @default.
- W2011129904 cites W2037057992 @default.
- W2011129904 cites W2047424764 @default.
- W2011129904 cites W2064710056 @default.
- W2011129904 cites W2072393293 @default.
- W2011129904 cites W2077954297 @default.
- W2011129904 cites W2085492709 @default.
- W2011129904 cites W2100491916 @default.
- W2011129904 cites W2107884608 @default.
- W2011129904 cites W2135913162 @default.
- W2011129904 cites W2140378849 @default.
- W2011129904 cites W2141884708 @default.
- W2011129904 cites W2151703323 @default.
- W2011129904 cites W2154061285 @default.
- W2011129904 cites W2157109097 @default.
- W2011129904 cites W2158972275 @default.
- W2011129904 cites W2165316408 @default.
- W2011129904 cites W2170069789 @default.
- W2011129904 doi "https://doi.org/10.1159/000089749" @default.
- W2011129904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16293970" @default.
- W2011129904 hasPublicationYear "2005" @default.
- W2011129904 type Work @default.
- W2011129904 sameAs 2011129904 @default.
- W2011129904 citedByCount "15" @default.
- W2011129904 countsByYear W20111299042012 @default.
- W2011129904 countsByYear W20111299042013 @default.
- W2011129904 countsByYear W20111299042017 @default.
- W2011129904 crossrefType "journal-article" @default.
- W2011129904 hasAuthorship W2011129904A5005771821 @default.
- W2011129904 hasAuthorship W2011129904A5017410860 @default.
- W2011129904 hasAuthorship W2011129904A5025025019 @default.
- W2011129904 hasAuthorship W2011129904A5040645190 @default.
- W2011129904 hasConcept C126322002 @default.
- W2011129904 hasConcept C203014093 @default.
- W2011129904 hasConcept C204232928 @default.
- W2011129904 hasConcept C2777858994 @default.
- W2011129904 hasConcept C502942594 @default.
- W2011129904 hasConcept C54009773 @default.
- W2011129904 hasConcept C54355233 @default.
- W2011129904 hasConcept C71924100 @default.
- W2011129904 hasConcept C81885089 @default.
- W2011129904 hasConcept C86803240 @default.
- W2011129904 hasConceptScore W2011129904C126322002 @default.
- W2011129904 hasConceptScore W2011129904C203014093 @default.
- W2011129904 hasConceptScore W2011129904C204232928 @default.
- W2011129904 hasConceptScore W2011129904C2777858994 @default.
- W2011129904 hasConceptScore W2011129904C502942594 @default.
- W2011129904 hasConceptScore W2011129904C54009773 @default.
- W2011129904 hasConceptScore W2011129904C54355233 @default.
- W2011129904 hasConceptScore W2011129904C71924100 @default.
- W2011129904 hasConceptScore W2011129904C81885089 @default.
- W2011129904 hasConceptScore W2011129904C86803240 @default.
- W2011129904 hasIssue "1" @default.
- W2011129904 hasLocation W20111299041 @default.
- W2011129904 hasLocation W20111299042 @default.
- W2011129904 hasOpenAccess W2011129904 @default.
- W2011129904 hasPrimaryLocation W20111299041 @default.
- W2011129904 hasRelatedWork W1978794790 @default.
- W2011129904 hasRelatedWork W2072607348 @default.
- W2011129904 hasRelatedWork W2126503388 @default.
- W2011129904 hasRelatedWork W2134823276 @default.
- W2011129904 hasRelatedWork W2285828597 @default.
- W2011129904 hasRelatedWork W2353769833 @default.
- W2011129904 hasRelatedWork W2368480016 @default.
- W2011129904 hasRelatedWork W2423356321 @default.
- W2011129904 hasRelatedWork W2461801986 @default.
- W2011129904 hasRelatedWork W2469005932 @default.
- W2011129904 hasVolume "82" @default.
- W2011129904 isParatext "false" @default.
- W2011129904 isRetracted "false" @default.
- W2011129904 magId "2011129904" @default.
- W2011129904 workType "article" @default.