FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011131439> ?p ?o ?g. }

• W2011131439 endingPage "135" @default.
• W2011131439 startingPage "116" @default.
• W2011131439 abstract "Salmonella enterica serovar Typhi is a human enteroinvasive pathogen that canovercome the stress caused by the high osmolarity of the human small intestine and causesystemic infection. To investigate the global transcriptional regulations of S. entericaserovar Typhi exposed to a hyperosmotic environment, a genomic oligo-DNA microarraycontaining 4474 Salmonella genes was prepared. A wild strain of S. enterica serovar TyphiGIFU10007 was grown in LB medium containing 50 mM NaCl to simulate a low osmoticenvironment. The hyperosmotic stress was simulated by an osmotic up-shift, whichincreased the concentration of NaCl in the LB from 50 mM to 300 mM. Genome-wide geneexpressions of S. enterica serovar Typhi at 15 min, 30 min, 60 min, and 120 min after theosmotic up-shift were investigated by the microarray analysis. Gene expression profiles insomewhat later stage (60 ~120 min) of the stress were quite different from those in the earlystage (0 ~ 30 min) of the stress. At 120 min after the osmotic stress, the expression levels of889 genes were obviously changed. However, expression levels of only 382 genes weresignificantly changed at 15 min after the osmotic stress. The expression levels of most SPI-1genes associated with invasion of the pathogen were increased at 120 min after the osmoticup-shift, but were not obviously changed at 15 min or 30 min after the osmotic stress.Expressions of a central regulatory gene, phoP, and sigma factor genes rpoE, rpoD, andrpoS were also changed with different profiles during the osmotic stress. These resultsindicated that the invasive ability of the pathogen is significantly increased after 2 h of hyperosmotic stress, and regulator PhoP and sigma factors RpoE, RpoD appear to participate in the network regulatory mechanisms that benefit the pathogen to adapt hyperosmotic environmental conditions. The later increased invasive ability of S. enterica serovar Typhi after hyperosmotic stress may be one reason why the pathogen performs invading in the distal ileum of human and not in areas of the upper small intestine." @default.
• W2011131439 created "2016-06-24" @default.
• W2011131439 creator A5001643051 @default.
• W2011131439 creator A5038300078 @default.
• W2011131439 creator A5044241067 @default.
• W2011131439 creator A5054911802 @default.
• W2011131439 creator A5084612475 @default.
• W2011131439 creator A5084692789 @default.
• W2011131439 date "2007-02-16" @default.
• W2011131439 modified "2023-10-16" @default.
• W2011131439 title "Genome-Wide Scan of the Gene Expression Kinetics of Salmonella enterica Serovar Typhi during Hyperosmotic Stress" @default.
• W2011131439 cites W1495526149 @default.
• W2011131439 cites W1515974038 @default.
• W2011131439 cites W1577548018 @default.
• W2011131439 cites W1586518876 @default.
• W2011131439 cites W1649550942 @default.
• W2011131439 cites W1748794332 @default.
• W2011131439 cites W1757579909 @default.
• W2011131439 cites W1915631326 @default.
• W2011131439 cites W1918966211 @default.
• W2011131439 cites W1921367924 @default.
• W2011131439 cites W1966350980 @default.
• W2011131439 cites W1970051171 @default.
• W2011131439 cites W1989712933 @default.
• W2011131439 cites W1992704705 @default.
• W2011131439 cites W2000917960 @default.
• W2011131439 cites W2002510848 @default.
• W2011131439 cites W2002555136 @default.
• W2011131439 cites W2005607229 @default.
• W2011131439 cites W2006495385 @default.
• W2011131439 cites W2021625212 @default.
• W2011131439 cites W2022874528 @default.
• W2011131439 cites W2042488059 @default.
• W2011131439 cites W2047222805 @default.
• W2011131439 cites W2053365008 @default.
• W2011131439 cites W2063302120 @default.
• W2011131439 cites W2064488801 @default.
• W2011131439 cites W2078742086 @default.
• W2011131439 cites W2087324903 @default.
• W2011131439 cites W2092808125 @default.
• W2011131439 cites W2099000249 @default.
• W2011131439 cites W2100231871 @default.
• W2011131439 cites W2103016908 @default.
• W2011131439 cites W2105582195 @default.
• W2011131439 cites W2116413722 @default.
• W2011131439 cites W2116548822 @default.
• W2011131439 cites W2123106708 @default.
• W2011131439 cites W2123269578 @default.
• W2011131439 cites W2123374042 @default.
• W2011131439 cites W2124008391 @default.
• W2011131439 cites W2124245050 @default.
• W2011131439 cites W2130424990 @default.
• W2011131439 cites W2142117803 @default.
• W2011131439 cites W2143939511 @default.
• W2011131439 cites W2144573392 @default.
• W2011131439 cites W2146606085 @default.
• W2011131439 cites W2150626270 @default.
• W2011131439 cites W2152059708 @default.
• W2011131439 cites W2153352437 @default.
• W2011131439 cites W2155955109 @default.
• W2011131439 cites W2157598793 @default.
• W2011131439 cites W2158279787 @default.
• W2011131439 cites W2158804540 @default.
• W2011131439 cites W2160170449 @default.
• W2011131439 cites W2163107957 @default.
• W2011131439 cites W2170647386 @default.
• W2011131439 cites W2170698461 @default.
• W2011131439 cites W2189215706 @default.
• W2011131439 cites W2260017570 @default.
• W2011131439 cites W2335362530 @default.
• W2011131439 cites W4250644598 @default.
• W2011131439 doi "https://doi.org/10.3390/i8020116" @default.
• W2011131439 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3666050" @default.
• W2011131439 hasPublicationYear "2007" @default.
• W2011131439 type Work @default.
• W2011131439 sameAs 2011131439 @default.
• W2011131439 citedByCount "24" @default.
• W2011131439 countsByYear W20111314392012 @default.
• W2011131439 countsByYear W20111314392013 @default.
• W2011131439 countsByYear W20111314392014 @default.
• W2011131439 countsByYear W20111314392016 @default.
• W2011131439 countsByYear W20111314392018 @default.
• W2011131439 countsByYear W20111314392019 @default.
• W2011131439 countsByYear W20111314392020 @default.
• W2011131439 countsByYear W20111314392021 @default.
• W2011131439 crossrefType "journal-article" @default.
• W2011131439 hasAuthorship W2011131439A5001643051 @default.
• W2011131439 hasAuthorship W2011131439A5038300078 @default.
• W2011131439 hasAuthorship W2011131439A5044241067 @default.
• W2011131439 hasAuthorship W2011131439A5054911802 @default.
• W2011131439 hasAuthorship W2011131439A5084612475 @default.
• W2011131439 hasAuthorship W2011131439A5084692789 @default.
• W2011131439 hasBestOaLocation W20111314391 @default.
• W2011131439 hasConcept C104317684 @default.
• W2011131439 hasConcept C105702510 @default.
• W2011131439 hasConcept C129900496 @default.
• W2011131439 hasConcept C150194340 @default.
• W2011131439 hasConcept C168529131 @default.

• next