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- W2011132353 abstract "In the present study, we have examined by light and electron microscopy whether SL 82.0715, a polyamine site-directed N-methyl-d-aspartate (NMDA) antagonist, causes pathological changes in cerebrocortical neurons similar to those observed with NMDA receptor channel blockers in the rat brain. Dizocilpine (1, 2 and 5 mg·kg−1, s.c.) induced a dose-dependent vacuolization of the neuronal cytoplasm in specific neurons of the retrosplenial and posterior cingulate cortices (layers III and IV) even at the lowest dose studied, at 6 h post-injection. In contrast, SL 82.0715 (10 and 30 mg·kg−1 i.p., 6 h post-injection) did not induce such morphological alterations. These results indicate that NMDA receptor blockade is not necessarily associated with alterations of cortical neuronal morphology." @default.
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- W2011132353 date "1992-03-01" @default.
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- W2011132353 title "SL 82.0715, an NMDA antagonist acting at the polyamine site, does not induce neurotoxic effects on rat cortical neurons" @default.
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- W2011132353 doi "https://doi.org/10.1016/0304-3940(92)90402-s" @default.
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