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- W2011146757 abstract "DAPH (4,5-dianilinophthalimide) has previously been shown to reverse the formation of neurotoxic fibrils associated with Alzheimer's disease. We have developed a synthetic route to DAPH and structurally related analogues that employs palladium-catalyzed amination as the key bond-forming step. The requisite substrates are easily obtained, and their coupling with substituted anilines proceeds in generally high yields. Thus, a variety of DAPH analogues can be quickly accessed in a modular fashion. In addition, the route described herein should also be amenable to the incorporation of other classes of nucleophiles into the molecular framework." @default.
- W2011146757 created "2016-06-24" @default.
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- W2011146757 date "2005-08-06" @default.
- W2011146757 modified "2023-09-27" @default.
- W2011146757 title "Synthesis of 4,5-Dianilinophthalimide and Related Analogues for Potential Treatment of Alzheimer's Disease via Palladium-Catalyzed Amination" @default.
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- W2011146757 doi "https://doi.org/10.1021/jo051096o" @default.
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