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• W2011157730 endingPage "165" @default.
• W2011157730 startingPage "165" @default.
• W2011157730 abstract "Hepatocellular carcinoma (HCC) is one of the most common and deadly cancers worldwide. In ninety percent of the cases it develops as a result of chronic liver damage and it is thus a typical inflammation-related cancer characterized by the close relation between the tumor microenvironment and tumor cells. The stromal environment consists out of several cell types, including hepatic stellate cells, macrophages and endothelial cells. They are not just active bystanders in the pathogenesis of HCC, but play an important and active role in tumor initiation, progression and metastasis. Furthermore, the tumor itself influences these cells to create a background that is beneficial for sustaining tumor growth. One of the key players is the hepatic stellate cell, which is activated during liver damage and differentiates towards a myofibroblast-like cell. Activated stellate cells are responsible for the deposition of extracellular matrix, increase the production of angiogenic factors and stimulate the recruitment of macrophages. The increase of angiogenic factors (which are secreted by macrophages, tumor cells and activated stellate cells) will induce the formation of new blood vessels, thereby supplying the tumor with more oxygen and nutrients, thus supporting tumor growth and offering a passageway in the circulatory system. In addition, the secretion of chemokines by the tumor cells leads to the recruitment of tumor associated macrophages. These tumor associated macrophages are key actors of cancer-related inflammation, being the main type of inflammatory cells infiltrating the tumor environment and exerting a tumor promoting effect by secreting growth factors, stimulating angiogenesis and influencing the activation of stellate cells. This complex interplay between the several cell types involved in liver cancer emphasizes the need for targeting the tumor stroma in HCC patients." @default.
• W2011157730 created "2016-06-24" @default.
• W2011157730 creator A5066856648 @default.
• W2011157730 creator A5077340506 @default.
• W2011157730 date "2014-01-01" @default.
• W2011157730 modified "2023-09-23" @default.
• W2011157730 title "Targeting the tumor stroma in hepatocellular carcinoma" @default.
• W2011157730 cites W1484083850 @default.
• W2011157730 cites W1486451451 @default.
• W2011157730 cites W1525131136 @default.
• W2011157730 cites W1538245709 @default.
• W2011157730 cites W1593389454 @default.
• W2011157730 cites W1933754980 @default.
• W2011157730 cites W1964100554 @default.
• W2011157730 cites W1968557245 @default.
• W2011157730 cites W1970776952 @default.
• W2011157730 cites W1970986474 @default.
• W2011157730 cites W1971837077 @default.
• W2011157730 cites W1972002349 @default.
• W2011157730 cites W1974203539 @default.
• W2011157730 cites W1976599453 @default.
• W2011157730 cites W1981187143 @default.
• W2011157730 cites W1987062221 @default.
• W2011157730 cites W1988737337 @default.
• W2011157730 cites W1991999538 @default.
• W2011157730 cites W1993234460 @default.
• W2011157730 cites W1996106353 @default.
• W2011157730 cites W1997285777 @default.
• W2011157730 cites W2000113015 @default.
• W2011157730 cites W2003112634 @default.
• W2011157730 cites W2004274458 @default.
• W2011157730 cites W2006570056 @default.
• W2011157730 cites W2006747130 @default.
• W2011157730 cites W2012222876 @default.
• W2011157730 cites W2013045785 @default.
• W2011157730 cites W2016364458 @default.
• W2011157730 cites W2016569548 @default.
• W2011157730 cites W2016828736 @default.
• W2011157730 cites W2018421775 @default.
• W2011157730 cites W2024811210 @default.
• W2011157730 cites W2028327679 @default.
• W2011157730 cites W2030881674 @default.
• W2011157730 cites W2032744185 @default.
• W2011157730 cites W2034548257 @default.
• W2011157730 cites W2041742398 @default.
• W2011157730 cites W2046000826 @default.
• W2011157730 cites W2051190668 @default.
• W2011157730 cites W2057923612 @default.
• W2011157730 cites W2059579379 @default.
• W2011157730 cites W2063992586 @default.
• W2011157730 cites W2064740570 @default.
• W2011157730 cites W2066013154 @default.
• W2011157730 cites W2066365544 @default.
• W2011157730 cites W2074325678 @default.
• W2011157730 cites W2074523891 @default.
• W2011157730 cites W2078478228 @default.
• W2011157730 cites W2081370217 @default.
• W2011157730 cites W2083142606 @default.
• W2011157730 cites W2083715308 @default.
• W2011157730 cites W2089907961 @default.
• W2011157730 cites W2092873757 @default.
• W2011157730 cites W2093189081 @default.
• W2011157730 cites W2100106896 @default.
• W2011157730 cites W2100297634 @default.
• W2011157730 cites W2102056525 @default.
• W2011157730 cites W2102880646 @default.
• W2011157730 cites W2106074495 @default.
• W2011157730 cites W2107144403 @default.
• W2011157730 cites W2111517972 @default.
• W2011157730 cites W2111691542 @default.
• W2011157730 cites W2113686775 @default.
• W2011157730 cites W2114012800 @default.
• W2011157730 cites W2115515762 @default.
• W2011157730 cites W2119242310 @default.
• W2011157730 cites W2121438383 @default.
• W2011157730 cites W2122129759 @default.
• W2011157730 cites W2122720689 @default.
• W2011157730 cites W2125410856 @default.
• W2011157730 cites W2128965737 @default.
• W2011157730 cites W2134233757 @default.
• W2011157730 cites W2136587516 @default.
• W2011157730 cites W2137562588 @default.
• W2011157730 cites W2139445236 @default.
• W2011157730 cites W2140088548 @default.
• W2011157730 cites W2144619904 @default.
• W2011157730 cites W2145803146 @default.
• W2011157730 cites W2146026405 @default.
• W2011157730 cites W2147817661 @default.
• W2011157730 cites W2147934487 @default.
• W2011157730 cites W2154807014 @default.
• W2011157730 cites W2156044485 @default.
• W2011157730 cites W2157367426 @default.
• W2011157730 cites W2163654664 @default.
• W2011157730 cites W2165447220 @default.
• W2011157730 cites W2165901246 @default.
• W2011157730 cites W2167289017 @default.
• W2011157730 cites W2167290534 @default.
• W2011157730 cites W2167761137 @default.

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