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• W2011171294 abstract "The development of technetium-99m-labeled small-molecule radiopharmaceuticals directed at specific high-affinity binding sites, as are found in receptors for hormones and neurotransmitters, transport systems, and certain enzymes, is a natural outgrowth from the successful development of technetium radiopharmaceuticals for imaging flow and metabolism. Although many receptor-specific radiopharmaceuticals labeled with PET and other SPECT isotopes already exist, the low cost and widespread availability of technetium-99m would make their 99mTc-labeled counterparts much more accessible to the medical community. This review has four goals: (a) To survey and analyze critically the results of a flurry of research activity in this area in recent years, which has led to the preparation of a number of novel technetium-labeled radiopharmaceuticals targeted at high-affinity sites, a few of which appear to be very promising; (b) to provide a conceptual analysis of how these agents are being designed; (c) to provide a context in terms of binding and uptake behavior by which these agents should be judged; and (d) to highlight emerging knowledge on the structure of receptors and related high-affinity binding biomolecules and their distribution, which may serve as reference points for understanding the results that have been obtained so far, and may be useful guides for future design." @default.
• W2011171294 created "2016-06-24" @default.
• W2011171294 creator A5050423461 @default.
• W2011171294 creator A5054090841 @default.
• W2011171294 date "1997-08-01" @default.
• W2011171294 modified "2023-10-18" @default.
• W2011171294 title "Technetium-99m-labeled receptor-specific small-molecule radiopharmaceuticals: Recent developments and encouraging results" @default.
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• W2011171294 doi "https://doi.org/10.1016/s0969-8051(97)00066-8" @default.
• W2011171294 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9316075" @default.
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