FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011172287> ?p ?o ?g. }

• W2011172287 endingPage "5714" @default.
• W2011172287 startingPage "5705" @default.
• W2011172287 abstract "Cyclooxygenase-2 (COX-2) mRNA is induced in the majority of human colorectal carcinomas. Transcriptional regulation plays a key role in COX-2 expression in human colon carcinoma cells, but post-transcriptional regulation of its mRNA is also critical for tumorigenesis. Expression of COX-2 mRNA is regulated by various cytokines, growth factors and other signals. beta-Catenin, a key transcription factor in the Wnt signal pathway, activates transcription of COX-2. Here we found that COX-2 mRNA was also substantially stabilized by activating beta-catenin in NIH3T3 and 293T cells. We identified the beta-catenin-responsive element in the proximal region of the COX-2 3'-untranslated region (3'-UTR) and showed that beta-catenin interacted with AU-rich elements (ARE) of 3'-UTR in vitro and in vivo. Interestingly, beta-catenin induced the cytoplasmic localization of the RNA stabilizing factor, HuR, which may bind to beta-catenin in an RNA-mediated complex and facilitate beta-catenin-dependent stabilization of COX-2 mRNA. Taken together, we provided evidences for beta-catenin as an RNA-binding factor and a regulator of stabilization of COX-2 mRNA." @default.
• W2011172287 created "2016-06-24" @default.
• W2011172287 creator A5062812749 @default.
• W2011172287 creator A5077769029 @default.
• W2011172287 date "2006-10-12" @default.
• W2011172287 modified "2023-09-27" @default.
• W2011172287 title "β-Catenin stabilizes Cyclooxygenase-2 mRNA by interacting with AU-rich elements of 3′-UTR" @default.
• W2011172287 cites W1491870867 @default.
• W2011172287 cites W1554815317 @default.
• W2011172287 cites W1907972050 @default.
• W2011172287 cites W1969196565 @default.
• W2011172287 cites W1975853332 @default.
• W2011172287 cites W1976185327 @default.
• W2011172287 cites W1979913744 @default.
• W2011172287 cites W1982266611 @default.
• W2011172287 cites W1993691900 @default.
• W2011172287 cites W1993748871 @default.
• W2011172287 cites W1994121712 @default.
• W2011172287 cites W2002404925 @default.
• W2011172287 cites W2006931677 @default.
• W2011172287 cites W2012781347 @default.
• W2011172287 cites W2014209078 @default.
• W2011172287 cites W2020522004 @default.
• W2011172287 cites W2029706883 @default.
• W2011172287 cites W2034030391 @default.
• W2011172287 cites W2036298061 @default.
• W2011172287 cites W2036864436 @default.
• W2011172287 cites W2046293893 @default.
• W2011172287 cites W2054872303 @default.
• W2011172287 cites W2056833504 @default.
• W2011172287 cites W2058192196 @default.
• W2011172287 cites W2072622898 @default.
• W2011172287 cites W2074915514 @default.
• W2011172287 cites W2083412264 @default.
• W2011172287 cites W2086510997 @default.
• W2011172287 cites W2088905899 @default.
• W2011172287 cites W2094484000 @default.
• W2011172287 cites W2100000108 @default.
• W2011172287 cites W2102606027 @default.
• W2011172287 cites W2107594198 @default.
• W2011172287 cites W2120764171 @default.
• W2011172287 cites W2122991629 @default.
• W2011172287 cites W2133141667 @default.
• W2011172287 cites W2134217283 @default.
• W2011172287 cites W2142789997 @default.
• W2011172287 cites W2152003287 @default.
• W2011172287 cites W2152432732 @default.
• W2011172287 cites W2155752136 @default.
• W2011172287 cites W2159376549 @default.
• W2011172287 cites W2171996338 @default.
• W2011172287 cites W2239090104 @default.
• W2011172287 doi "https://doi.org/10.1093/nar/gkl698" @default.
• W2011172287 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1636482" @default.
• W2011172287 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17040897" @default.
• W2011172287 hasPublicationYear "2006" @default.
• W2011172287 type Work @default.
• W2011172287 sameAs 2011172287 @default.
• W2011172287 citedByCount "67" @default.
• W2011172287 countsByYear W20111722872012 @default.
• W2011172287 countsByYear W20111722872013 @default.
• W2011172287 countsByYear W20111722872014 @default.
• W2011172287 countsByYear W20111722872015 @default.
• W2011172287 countsByYear W20111722872016 @default.
• W2011172287 countsByYear W20111722872018 @default.
• W2011172287 countsByYear W20111722872019 @default.
• W2011172287 countsByYear W20111722872020 @default.
• W2011172287 countsByYear W20111722872022 @default.
• W2011172287 countsByYear W20111722872023 @default.
• W2011172287 crossrefType "journal-article" @default.
• W2011172287 hasAuthorship W2011172287A5062812749 @default.
• W2011172287 hasAuthorship W2011172287A5077769029 @default.
• W2011172287 hasBestOaLocation W20111722871 @default.
• W2011172287 hasConcept C104317684 @default.
• W2011172287 hasConcept C105580179 @default.
• W2011172287 hasConcept C137620995 @default.
• W2011172287 hasConcept C138885662 @default.
• W2011172287 hasConcept C153911025 @default.
• W2011172287 hasConcept C179926584 @default.
• W2011172287 hasConcept C185622968 @default.
• W2011172287 hasConcept C22667442 @default.
• W2011172287 hasConcept C2779324961 @default.
• W2011172287 hasConcept C30145163 @default.
• W2011172287 hasConcept C41282012 @default.
• W2011172287 hasConcept C41895202 @default.
• W2011172287 hasConcept C502942594 @default.
• W2011172287 hasConcept C55493867 @default.
• W2011172287 hasConcept C62478195 @default.
• W2011172287 hasConcept C67705224 @default.
• W2011172287 hasConcept C86339819 @default.
• W2011172287 hasConcept C86803240 @default.
• W2011172287 hasConcept C89604277 @default.
• W2011172287 hasConcept C95444343 @default.
• W2011172287 hasConceptScore W2011172287C104317684 @default.
• W2011172287 hasConceptScore W2011172287C105580179 @default.
• W2011172287 hasConceptScore W2011172287C137620995 @default.
• W2011172287 hasConceptScore W2011172287C138885662 @default.
• W2011172287 hasConceptScore W2011172287C153911025 @default.
• W2011172287 hasConceptScore W2011172287C179926584 @default.

• next