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• W2011172495 abstract "Problems with communication and language are common in Alzheimer's disease (AD), and can lead to patient difficulties, including feelings of frustration and isolation. Therefore, our objective was to develop a scale for language assessment in AD (based on the Severe Impairment Battery, SIB), thereby also providing a means for analyzing the specific effects of treatment on language performance. The scale was generated using predefined language-related items from the SIB. Once the items had been selected, they were assessed by factor analysis, using baseline data from an AD database of 1,320 patients with moderate to severe AD, collated from four studies (IE2101, MD-01, MD-02, MRZ-9605). Correlations were calculated between the new language scale and existing scales. Of the 51 SIB items, 24 language-related items were initially chosen for inclusion in the new scale, which was designated the SIB Language (SIB-L) scale. Assessment of these items by principal components factor analysis revealed 6 factors, comprising 21 items with loadings >0.5. The resulting 21-item SIB-L showed a high level of internal consistency (Cronbach's α=0.8095). SIB-L has a maximum score of 41 points, with a measurement error of 3.7 points, and time for administration is <15 min. Comparison with existing scales revealed a correlation of r=0.697 between MMSE (mean 9.7, SD 3.3) and SIB-L (mean 31.7, SD 8.4) scores, demonstrating that MMSE has a low predictive value for language. Comparison of SIB-L with the original SIB scale (mean 73.9, SD 18.5) showed a strong correlation (r=0.943), but there was a very low correlation (r=-0.096) between SIB-L and the Neuropsychiatric Inventory (NPI, mean 16.5, SD 14.4). SIB-L scores were wide ranging in patients with moderate AD – even patients with very low MMSE scores – suggesting no substantial floor and ceiling effects. In SIB-L, we have developed a scale for assessing language performance that is easy and quick (<15 min) to administer to patients with moderate to severe AD. SIB-L will be a useful clinical tool for assessing the potential benefits of treatment on the important area of language in AD." @default.
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• W2011172495 date "2008-07-01" @default.
• W2011172495 modified "2023-10-02" @default.
• W2011172495 title "P3-009: Development of a language assessment tool for patients with Alzheimer's disease" @default.
• W2011172495 doi "https://doi.org/10.1016/j.jalz.2008.05.1572" @default.
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