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- W2011176251 abstract "The biocompatible thiol‐functionalized rGO SH /PMA SH microcapsules encapsulating nerve growth factor (NGF) are arrayed onto a transparent and conductive substrate, i.e., indium tin oxide (ITO), to integrate electrically stimulated cellular differentiation, electrically controlled NGF release, and topographically rough nano‐surfaces into a 3‐D platform for nerve regeneration. The rGO SH /PMA SH microcapsules with microscale topography function not only as an adhesive coating to promote the adhesion of PC12 cells but also as electroactive NGF‐releasing electrodes that stimulate NGF release and accelerate the differentiation of PC12 cells during electrical stimulation. Once electrical treatment is applied, NGF release and electrically enhanced cellular differentiation lead to an obvious increase both in the percentage of cells with neurites and in the neurite length. This length can reach nearly 90 μm within 2 days of cell culture. The average neurite length is significantly increased (four‐fold) after culture on the rGO SH /PMA SH microcapsule substrate for 2 days compared with culture on a substrate without an rGO SH /PMA SH coating. These multifunctional rGO SH /PMA SH microcapsules may be used as potential 3‐D patterned substrates for neural regeneration and neural prosthetics in tissue engineering applications." @default.
- W2011176251 created "2016-06-24" @default.
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- W2011176251 date "2014-03-04" @default.
- W2011176251 modified "2023-10-12" @default.
- W2011176251 title "Arrayed rGO<sub>SH</sub>/PMA<sub>SH</sub>Microcapsule Platform Integrating Surface Topography, Chemical Cues, and Electrical Stimulation for Three-Dimensional Neuron-Like Cell Growth and Neurite Sprouting" @default.
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- W2011176251 doi "https://doi.org/10.1002/adfm.201303853" @default.
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